Repetitive elements in the human genome, once considered 'junk DNA', are now known to
adopt more than a dozen alternative (that is, non-B) DNA structures, such as self-annealed …

Resistance to chemo-and radiotherapy is a common event among cancer patients and a
reason why new cancer therapies and therapeutic strategies need to be in continuous …

Reactive oxygen species (ROS) have emerged as important cellular-signaling agents for
cellular survival. Herein, we demonstrate that ROS-mediated oxidation of DNA to yield 8-oxo …

In this review article, emphasis is placed on the critical survey of available data concerning
modified nucleobase and 2-deoxyribose products that have been identified in cellular DNA …

Oxidative stress and the resulting damage to genomic DNA are inevitable consequences of
endogenous physiological processes, and they are amplified by cellular responses to …

Living in an oxygen atmosphere demands an ability to thrive in the presence of reactive
oxygen species (ROS). Aerobic organisms have successfully found solutions to the oxidative …

The six major mammalian DNA repair pathways were discovered as independent
processes, each dedicated to remove specific types of lesions, but the past two decades …

Oxidative DNA damage constitutes a major threat to genetic integrity, and has thus been
implicated in the pathogenesis of a wide variety of diseases, including cancer and …

A variety of endogenous and exogenous agents can induce DNA damage and lead to
genomic instability. Reactive oxygen species (ROS), an important class of DNA damaging …

Contrary to frequent reports in the literature, hydroxyl radical is not a key species
participating in endogenous oxidative DNA damage. Instead, carbonate radical anion is …