A number of studies have shown that metformin can delay aging process and extend healthy
lifespan in animals. However, its role in female reproductive lifespan is unclear. This study …

Once considered a tissue culture-specific phenomenon, cellular senescence has now been
linked to various biological processes with both beneficial and detrimental roles in humans …

Adipose tissue is recognized as a major source of systemic inflammation with age, driving
age‐related tissue dysfunction and pathogenesis. Macrophages (Mφ) are central to these …

Skin aging is accompanied by an increase in the number of senescent cells, resulting in
various pathological outcomes. These include inflammation, impaired barrier function, and …

Aging is a complex biological process that is inevitable for nearly all organisms. Aging is the
strongest risk factor for development of multiple neurodegenerative disorders, cancer and …

Mitochondrial dysfunction is a hallmark of cellular aging. Mitophagy is a critical
mitochondrial quality control mechanism that removes dysfunctional mitochondria and …

Background Hypertension may be associated with renal cellular injury. Cells in distress
release extracellular vesicles (EV s), and their numbers in urine may reflect renal injury …

Ageing is associated with increased vulnerability to environmental cold exposure.
Previously, we identified the role of the cold-sensitive transient receptor potential (TRP) A1 …

Cancer survivors may experience long-term cardiovascular complications due to
chemotherapeutic drugs such as doxorubicin (DOX). The exact mechanism of delayed DOX …

Brain aging is an inevitable process characterized by structural and functional changes and
is a major risk factor for neurodegenerative diseases. Most brain aging studies are focused …