Senolytic treatment in aged mice clears senescent cell burden leading to functional
improvements. However, less is known regarding the effects of these compounds when …

Once infected, hosts can rely on two strategies to cope with parasites: fight them (resist the
infection) or minimize the damage they induce (tolerate the infection). While there is …

Experimental autoimmune encephalomyelitis (EAE) is a demyelinating disease affecting the
central nervous system (CNS) in animals that parallels several clinical and molecular traits …

Ageing is a continuous process in life featuring progressive damage accumulation that leads
to physiological decline, functional deterioration and ultimately death of an organism. Based …

Cellular senescence is a state of growth arrest that occurs after cells encounter various
stresses. Senescence contributes to tumour suppression, embryonic development, and …

Purpose Lower urinary tract symptoms are known to significantly increase with age,
negatively impacting quality of life and self-reliance. The urothelium fulfills crucial tasks …

Accumulating evidence suggests that the sympathetic nervous system (SNS) overactivity
plays a crucial role in age-related increase in the risk for cardiovascular diseases such as …

DNA methylation patterns have been shown to change throughout the normal aging
process. Several studies have found epigenetic aging markers using age predictors, but …

Alveolar macrophages (AMs) are tissue-resident cells of the lower airways that perform
many homeostatic functions critical for pulmonary health and protection against pathogens …

Simple Summary Chemotherapy is a commonly applied anticancer treatment, however
therapy-induced senescent growth arrest has been associated with aggressive disease …