Omics data can be used to identify biological characteristics from genetic to phenotypic
levels during the life span of a living being, while molecular interaction networks have a …

Background: Epithelial to mesenchymal transition (EMT) is considered as one of the
senescence processes; reportedly, anti-senescence therapies effectively reduce EMT. Some …

With an aging population and the numerous health impacts associated with old age, the
identification of anti-aging drugs has become an important new research direction. Although …

Bladder dysfunction is associated with fibrosis-mediated aging, but the corresponding
mechanism remains to be elucidated. Activation of the NACHT, LRR and PYD domains …

Epilepsy is a complex clinical condition characterized by repeated spontaneous seizures.
Seizures have been linked to multiple drivers including DNA damage accumulation …

Senolytic treatment in aged mice clears senescent cell burden leading to functional
improvements. However, less is known regarding the effects of these compounds when …

Aging is a complex biological process involving multiple interacting mechanisms and is
being increasingly linked to environmental exposures such as wildfire smoke. In this review …

Describing evolutionary conserved physiological or molecular patterns, which can reliably
mark the age of both model organisms and humans or predict the onset of age-related …

摘要背景: 前期工作发现自噬相关基因Uvrag 缺失导致年龄相关心肌病, 但细胞衰老在此过程中
的作用尚不清楚. 目的: 研究Uvrag 基因缺失对心脏细胞衰老的影响. 方法: 从Uvrag …

Cellular senescence is described as an irreversible cell cycle arrest induced in response to
various stresses. Senescent cells are characterised by heterogeneous signalling alterations …