Impaired cognitive flexibility induced by chronic cerebral hypoperfusion in the 5XFAD transgenic mouse model of mixed dementia

MS Kim, J Bang, BY Kim, WK Jeon - The Journals of …, 2021 - academic.oup.com
Cerebrovascular lesions are widely prevalent in patients with Alzheimer's disease (AD), but
their relationship to the pathophysiology of AD remains poorly understood. An improved …

Adolescent stress accelerates postpartum novelty recognition impairment in 5xFAD mice

O Leitzel, J Francis-Oliveira, SM Khedr… - Frontiers in …, 2024 - frontiersin.org
Pregnancy and the postpartum period induce physiological changes that can influence
women's cognitive functions. Alzheimer's disease (AD) has a higher prevalence in women …

Alzheimer's disease and empathic abilities: the proposed role of the cingulate cortex

M Ávila-Villanueva, J Gómez-Ramírez… - Journal of …, 2021 - content.iospress.com
In recent years there has been increasing interest in examining the role of empathic abilities
in Alzheimer's disease (AD). Empathy, the ability to understand and share another person's …

Behaviour Hallmarks in Alzheimer's Disease 5xFAD Mouse Model

MS Pádua, JL Guil-Guerrero, PA Lopes - International Journal of …, 2024 - mdpi.com
The 5xFAD transgenic mouse model widely used in Alzheimer's disease (AD) research
recapitulates many AD-related phenotypes with a relatively early onset and aggressive age …

Loss of GDE2 leads to complex behavioral changes including memory impairment

D Daudelin, A Westerhaus, N Zhang, E Leyder… - Behavioral and Brain …, 2024 - Springer
Background Alzheimer's disease (AD) and amyotrophic lateral sclerosis/frontotemporal
dementia (ALS/FTD) are debilitating neurodegenerative diseases for which there are …

Reduced social investigation and increased injurious behavior in transgenic 5xFAD mice

F Kosel, JS Hamilton, SL Harrison… - Journal of …, 2021 - Wiley Online Library
Social withdrawal and agitation/aggression are common behavioral and psychological
symptoms of dementia presented by Alzheimer's disease (AD) patients, with males …

Shenqi Yizhi granules protect hippocampus of AD transgenic mice by modulating on multiple pathological processes

J Ren, D Wei, H An, J Zhang, Z Zhang - Journal of Ethnopharmacology, 2020 - Elsevier
Ethnopharmacological relevance Chinese herbal medicine (CHM) draws more attention to
explore effective therapeutic strategy for Alzheimer's disease (AD). CHM usually uses …

Neurobehavioral Analysis to Assess Olfactory and Motor Dysfunction in Parkinson's Disease

SR Panda, P Panja, U Soni, VGM Naidu - Neuroprotection: Method and …, 2024 - Springer
Parkinson's disease (PD) is the second most common neurodegenerative condition,
primarily affecting dopaminergic neurons. It is defined by motor impairments, such as …

Elevated testosterone level and urine scent marking in male 5xFAD Alzheimer model mice

L Gadomsky, M dos Santos Guilherme… - Current Alzheimer …, 2020 - ingentaconnect.com
Background: Function of the Amyloid Precursor Protein (AβPP) and its various cleavage
products still is not unraveled down to the last detail. While its role as a source of the …

Aberrant Cortical Activity in 5xFAD Mice in Response to Social and Non-Social Olfactory Stimuli

F Kosel, MR Hartley, TB Franklin - Journal of Alzheimer's …, 2023 - content.iospress.com
Background: Neuroimaging studies investigating the behavioral and psychological
symptoms of dementia (BPSD)—such as apathy, anxiety, and depression—have linked …