mRNA vaccines in the COVID-19 pandemic and beyond
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus
disease 2019 (COVID-19), emerged in China in December 2019 and quickly spread around …
disease 2019 (COVID-19), emerged in China in December 2019 and quickly spread around …
Adenoviral vector vaccine platforms in the SARS-CoV-2 pandemic
Adenoviral vectors have been explored as vaccine agents for a range of infectious diseases,
and their ability to induce a potent and balanced immune response made them logical …
and their ability to induce a potent and balanced immune response made them logical …
Biopharmaceutical benchmarks 2022
G Walsh, E Walsh - Nature Biotechnology, 2022 - nature.com
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Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses
Adjuvants are critical for improving the quality and magnitude of adaptive immune
responses to vaccination. Lipid nanoparticle (LNP)-encapsulated nucleoside-modified …
responses to vaccination. Lipid nanoparticle (LNP)-encapsulated nucleoside-modified …
[HTML][HTML] SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses
JS Turner, JA O'Halloran, E Kalaidina, W Kim… - Nature, 2021 - nature.com
Abstract SARS-CoV-2 mRNA-based vaccines are about 95% effective in preventing COVID-
19 1, 2, 3, 4, 5. The dynamics of antibody-secreting plasmablasts and germinal centre B …
19 1, 2, 3, 4, 5. The dynamics of antibody-secreting plasmablasts and germinal centre B …
Side effects of mRNA-based and viral vector-based COVID-19 vaccines among German healthcare workers
Simple Summary The main way to overcome the COVID-19 pandemic is mass vaccination of
the public. However, the public's vaccine hesitancy toward the available vaccines is a big …
the public. However, the public's vaccine hesitancy toward the available vaccines is a big …
Spheromers reveal robust T cell responses to the Pfizer/BioNTech vaccine and attenuated peripheral CD8+ T cell responses post SARS-CoV-2 infection
T cells are a critical component of the response to SARS-CoV-2, but their kinetics after
infection and vaccination are insufficiently understood. Using" spheromer" peptide-MHC …
infection and vaccination are insufficiently understood. Using" spheromer" peptide-MHC …
The impact of spike mutated variants of SARS-CoV2 [Alpha, Beta, Gamma, Delta, and Lambda] on the efficacy of subunit recombinant vaccines
M Mohammadi, M Shayestehpour… - Brazilian Journal of …, 2021 - SciELO Brasil
Since the first described human infection with SARS-CoV-2 in December of 2019 many
subunit protein vaccines have been proposed for use in humans. Subunit vaccines use one …
subunit protein vaccines have been proposed for use in humans. Subunit vaccines use one …
Messenger RNA-based vaccines: Past, present, and future directions in the context of the COVID-19 pandemic
Abstract mRNA vaccines have received major attention in the fight against COVID-19.
Formulations from companies such as Moderna and BioNTech/Pfizer have allowed us to …
Formulations from companies such as Moderna and BioNTech/Pfizer have allowed us to …
[HTML][HTML] Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals
Vaccine-mediated immunity often relies on the generation of protective antibodies and
memory B cells, which commonly stem from germinal center (GC) reactions. An in-depth …
memory B cells, which commonly stem from germinal center (GC) reactions. An in-depth …