The current understanding of lactate extends from its origins as a byproduct of glycolysis to
its role in tumor metabolism, as identified by studies on the Warburg effect. The lactate …

The pathogenesis of idiopathic pulmonary fibrosis (IPF) involves a complex interplay of cell
types and signaling pathways. Recurrent alveolar epithelial cell (AEC) injury may occur in …

Metabolites of glycolytic metabolism have been identified as signaling molecules and
regulators of gene expression, in addition to their basic function as major energy and …

Fibrosis progression in the lung commonly results in impaired functional gas exchange,
respiratory failure, or even death. In addition to the aberrant activation and differentiation of …

Background: Inflammation resolution and cardiac repair initiation after myocardial infarction
(MI) require timely activation of reparative signals. Histone lactylation confers macrophage …

Lactate is an end product of glycolysis. As a critical energy source for mitochondrial
respiration, lactate also acts as a precursor of gluconeogenesis and a signaling molecule …

Lactate has diverse roles in the brain at the molecular and behavioral levels under
physiological and pathophysiological conditions. This study investigates whether lysine …

Background Histone lactylation has been recently described as a novel histone post-
translational modification linking cellular metabolism to epigenetic regulation. Results Given …

Metabolic reprogramming is involved in the pathogenesis of not only cancers but also
neurodegenerative diseases, cardiovascular diseases, and infectious diseases. With the …

Lactate is not only an endpoint of glycolysis but is gradually being discovered to play the
role of a universal metabolic fuel for energy via the 'lactate shuttle'moving between cells and …