Despite the medical advances and interventions to improve the quality of life of those in
intensive care, people with cancer or severely immunocompromised or other susceptible …

Sensing, responding, and adapting to the surrounding environment are crucial for all living
organisms to survive, proliferate, and differentiate in their biological niches. This ability is …

Brain infection by the fungus Cryptococcus neoformans results in an estimated 500,000
human deaths per annum. Colonization of the central nervous system (CNS) by C …

Cryptococcosis, caused by Cryptococcus neoformans, has been demonstrated to be
controlled by T helper (Th) 1 cells while Th2 cells are associated with fungal growth and …

Cryptococcus-macrophage interaction is crucial in the development of cryptococcocal
diseases. C. neoformans and C. gattii are major pathogenic species that occupy different …

Cryptococcus species are encapsulated fungi found in the environment that predominantly
cause disease in immunocompromised hosts after inhalation into the lungs. Even with …

In previous studies, we determined that the F-box protein Fbp1, a subunit of the SCF (Fbp1)
E3 ligase in Cryptococcus neoformans, is essential for fungal pathogenesis. Heat-killed …

Cryptococcus neoformans is an opportunistic fungal pathogen, which causes life‐
threatening meningoencephalitis in immunocompromised individuals and is responsible for …

ABSTRACT Cryptococcus neoformans:(H99W) was serially passaged in the invertebrate
wax moth Galleria mellonella fifteen times to study how fungal virulence evolves under …

Cryptococcus species are fungal pathogens that are a leading cause of mortality. Initial
inoculation is through the pulmonary route and, if disseminated, results in severe invasive …