Structural plasticity of dendritic spines and synapses is an essential mechanism to sustain
long lasting changes in the brain with learning and experience. The use of electron …

Nascent zones and active zones are adjacent synaptic regions that share a postsynaptic
density, but nascent zones lack the presynaptic vesicles found at active zones. Here …

Synaptic vesicles are responsible for releasing neurotransmitters and are thus essential to
brain function. The classical mode of vesicle recycling includes full collapse of the vesicle …

Tomosyn is a large, non-canonical SNARE protein proposed to act as an inhibitor of SNARE
complex formation in the exocytosis of secretory vesicles. In the brain, tomosyn inhibits the …

Deciphering the cellular and molecular mechanisms of memory has been an important topic
encompassing the learning and memory domain besides the neurodegenerative disorders …

Background Cerebrospinal fluid (CSF) contacts many brain regions and may mediate
humoral signaling distinct from synaptic neurotransmission. However, synthesis and …

Many cellular processes depend on a precise structural organization of molecular
components. Here, we established that neurons grown in culture provide a suitable system …

The frog neuromuscular junction (NMJ) is a strong and reliable synapse because, during
activation, sufficient neurotransmitter is released to trigger a postsynaptic action potential …

Vesicle pool properties are known determinants of synaptic efficacy, but their potential role
as modifiable substrates in forms of Hebbian plasticity is still unclear. Here, we investigate …

Microtubule-associated protein 1B (MAP1B) is expressed predominantly during the early
stages of development of the nervous system, where it regulates processes such as axonal …