The present article provides a detailed concept of the role of NLRP3 inflammasome in the
pathophysiology of depression-like chronic diseases where inflammation and release of …

The involvement of central and peripheral inflammation in the pathogenesis and prognosis
of major depressive disorder (MDD) has been demonstrated. The increase of pro …

Recent extensive evidence suggests that ambient fine particulate matter (PM2. 5, with an
aerodynamic diameter≤ 2.5 μm) may be neurotoxic to the brain and cause central nervous …

Major depressive disorder (MDD) has a high prevalence and is a major contributor to the
global burden of disease. This psychiatric disorder results from a complex interaction …

Previous studies have demonstrated a bidirectional relationship between inflammation and
depression. Activation of the nucleotide-binding oligomerization domain, leucine-rich repeat …

Objective: Inflammatory cytokines disturbance is the main result of immune dysregulation,
which is widely described in major depressive disorder (MDD). However, the potential …

Neuroinflammation is the common pathological feature of neuropsychiatric diseases.
Chrysin, a kind of natural flavonoid compound, was reported to exert antidepressant effects …

Objective Chronic obstructive pulmonary disease (COPD) is a well-known complex
multicomponent disease characterized by systemic inflammation that frequently coexists …

Background Increasing evidence suggests that early life stress (ELS) and
neuroinflammation are associated with the pathophysiology of depression. The purpose of …

Recent studies had reported that compounds that stimulate microglia could be developed as
potential drugs for the treatment of depression due to their reversal effect on depression-like …