I. Introduction B ETWEEN 1968 and 1973 a large body of evidence accumulated in our
laboratory and by others demonstrated that the conversion of testosterone to …

Abstract Individuals with 5α-reductase-2 deficiency (5α-RD-2) and 17β-hydroxysteroid
dehydrogenase-3 deficiency (17β-HSD-3) are often raised as girls. Over the past number of …

People born with physical intersex conditions (often better known as hermaphroditism)
remind us that the ordinary or" normal" process of physical sex differentiation is by no means …

The enzyme steroid 5a-reductase utilizes NADPH to reduce the double bonds of a variety of
steroid substrates with generalized 3-oxo, A4'5 structures. One substrate for this membrane …

Seventeen individuals from a pedigree with complete androgen insensitivity,[testicular
feminization (TF)] are presented. Their hormonal evaluation was compared with those of …

A simplified, rapid, and highly reproducible technique is described for measuring 5α-
reductase activity (5αRA) in small skin biopsies. Human genital skin was obtained from 23 …

Excess body hair, or hirsutism, is usually only a problem in women and can cause
considerable psychological distress. The disorder is usually androgen mediated. Because …

A male infant with perineal hypospadias and a small phallus bound in chordee is described.
Biochemical investigation at age 9 months after hCG stimulation revealed a testosterone to …

The clinical presentation of disorders of androgen production or action varies greatly,
depending on the age and sex of the patient. At birth and during infancy, the main problems …

Male subjects administered the 5 α-reductase inhibitor finasteride were studied to determine
its effect on C19 and C21 5 α-metabolism. Plasma testosterone (T) and 5 α …