Over the last two decades, a novel subgroup of serine proteases, the cell surface–anchored
serine proteases, has emerged as an important component of the human degradome, and …

Since the discovery of MSP (macrophage-stimulating protein; also known as MST1 and
hepatocyte growth factor-like (HGFL)) as the ligand for the receptor tyrosine kinase RON …

Pericellular proteases have long been implicated in carcinogenesis. Previous research
focused on these proteins, primarily as extracellular matrix (ECM) protein‐degrading …

Uromodulin is the most abundant protein in the urine. It is exclusively produced by renal
epithelial cells and it plays key roles in kidney function and disease. Uromodulin mainly …

Hepsin is required for the growth and maintenance of normal morphology, as well as for cell
motility and development, initiation of blood coagulation and pro-inflammatory immune …

A vast ensemble of extracellular proteins influences the development and progression of
cancer, shaped and reshaped by a complex network of extracellular proteases. These …

Cell membrane‐bound serine proteases are important in the maintenance of physiological
homeostasis. Hepsin is a type II transmembrane serine protease highly expressed in the …

By virtue of its amplifying property, the alternative complement pathway has been implicated
in a number of inflammatory diseases and constitutes an attractive therapeutic target. An anti …

Although amplifications and mutations in receptor tyrosine kinases (RTKs) act as bona fide
oncogenes, in most cancers, RTKs maintain moderate expression and remain wild-type …

More than 2% of all human genes are coding for a complex system of more than 700
proteases and protease inhibitors. Among them, serine proteases play extraordinary …