5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

The hippocampus plays an important role in emotional and cognitive processing, and both
of these domains are affected in patients with major depressive disorder (MDD). Extensive …

The efficacy and duration of memory storage is regulated by neuromodulatory transmitter
actions. While the modulatory transmitter serotonin (5-HT) plays an important role in implicit …

It has been known for several decades that serotonergic neurotransmission is a key
regulator of cognitive function, mood, and sleep. Yet with the relatively recent discoveries of …

Diverse neuropsychiatric disorders present dysfunctional memory and no effective treatment
exits for them; likely as result of the absence of neural markers associated to memory …

Cognitive deficits commonly accompany psychiatric disorders but are often
underrecognised, and difficult to treat. The 5-HT 4 receptor is a promising potential treatment …

Major depressive disorder (MDD) is primarily conceptualized as a mood disorder but
cognitive dysfunction is also prevalent, and may limit the daily function of MDD patients …

The serotonin 4 receptor, 5-HT4R, represents one of seven different serotonin receptor
families and is implicated in a variety of physiological functions and their pathophysiological …

Animal experimental studies suggest that 5-HT4 receptor activation holds promise as a
novel target for the treatment of depression and cognitive impairment. 5-HT4 receptors are …

A single iv infusion of ketamine, classified as an N-methyl-d-aspartate (NMDA) receptor
antagonist, may alleviate depressive symptoms within hours of administration in treatment …