Contribution of adipogenesis to healthy adipose tissue expansion in obesity

L Vishvanath, RK Gupta - The Journal of clinical …, 2019 - Am Soc Clin Investig
The manner in which white adipose tissue (WAT) expands and remodels directly impacts the
risk of developing metabolic syndrome in obesity. Preferential accumulation of visceral WAT …

Adipogenesis: a complex interplay of multiple molecular determinants and pathways

MA Ambele, P Dhanraj, R Giles, MS Pepper - International journal of …, 2020 - mdpi.com
The formation of adipocytes during embryogenesis has been largely understudied.
However, preadipocytes appear to originate from multipotent mesenchymal stromal/stem …

[HTML][HTML] Ginsenosides for the treatment of metabolic syndrome and cardiovascular diseases: Pharmacology and mechanisms

W Fan, Y Huang, H Zheng, S Li, Z Li, L Yuan… - Biomedicine & …, 2020 - Elsevier
Epidemiological studies showed that the metabolic syndromes (MetS) and cardiovascular
diseases (CVDs) are responsible for a serious threat to human health worldwide. MetS is a …

Exosome-derived microRNAs of human milk and their effects on infant health and development

BC Melnik, W Stremmel, R Weiskirchen, SM John… - Biomolecules, 2021 - mdpi.com
Multiple biologically active components of human milk support infant growth, health and
development. Milk provides a wide spectrum of mammary epithelial cell-derived …

[HTML][HTML] Adipose tissue: physiology to metabolic dysfunction

AJ Richard, U White, CM Elks, JM Stephens - Endotext [Internet], 2020 - ncbi.nlm.nih.gov
Like the obesity epidemic, our understanding of adipocytes and adipose tissue is
expanding. Just in the past decade, substantial advances have led to new insights into the …

Regulatory mechanisms of the early phase of white adipocyte differentiation: An overview

M Audano, S Pedretti, D Caruso, M Crestani… - Cellular and molecular …, 2022 - Springer
The adipose organ comprises two main fat depots termed white and brown adipose tissues.
Adipogenesis is a process leading to newly differentiated adipocytes starting from precursor …

High-dimensional gene expression and morphology profiles of cells across 28,000 genetic and chemical perturbations

M Haghighi, JC Caicedo, BA Cimini, AE Carpenter… - Nature …, 2022 - nature.com
Cells can be perturbed by various chemical and genetic treatments and the impact on gene
expression and morphology can be measured via transcriptomic profiling and image-based …

Protective effects of licochalcone A ameliorates obesity and non-alcoholic fatty liver disease via promotion of the Sirt-1/AMPK pathway in mice fed a high-fat diet

CJ Liou, YK Lee, NC Ting, YL Chen, SC Shen, SJ Wu… - Cells, 2019 - mdpi.com
Licochalcone A is a chalcone isolated from Glycyrrhiza uralensis. It showed anti-tumor and
anti-inflammatory properties in mice with acute lung injuries and regulated lipid metabolism …

Adipose tissue aging: mechanisms and therapeutic implications

MY Ou, H Zhang, PC Tan, SB Zhou, QF Li - Cell death & disease, 2022 - nature.com
Adipose tissue, which is the crucial energy reservoir and endocrine organ for the
maintenance of systemic glucose, lipid, and energy homeostasis, undergoes significant …

Three chromosome-level duck genome assemblies provide insights into genomic variation during domestication

F Zhu, ZT Yin, Z Wang, J Smith, F Zhang… - Nature …, 2021 - nature.com
Domestic ducks are raised for meat, eggs and feather down, and almost all varieties are
descended from the Mallard (Anas platyrhynchos). Here, we report chromosome-level high …