Although multiple pancreatic islet single-cell RNA-sequencing (scRNA-seq) datasets have
been generated, a consensus on pancreatic cell states in development, homeostasis and …

Replacement of diseased organs with transplanted healthy donor ones remains the best
and often only treatment option for end-stage organ disease. Immunosuppressants have …

The main hallmark in the development of both type 1 and type 2 diabetes is a decline in
functional β-cell mass. This decline is predominantly attributed to β-cell death, although …

The rete ovarii (RO) is an epithelial structure that arises during development in close
proximity to the ovary and persists throughout adulthood. However, the functional …

Background M. leprae preferentially infects Schwann cells (SCs) in the peripheral nerves
leading to nerve damage and irreversible disability. Knowledge of how M. leprae infects and …

Background Current approaches to profile the single-cell transcriptomics of human
pancreatic endocrine cells almost exclusively rely on freshly isolated islets. However, human …

Cellular identity during development is under the control of transcription factors that form
gene regulatory networks. However, the transcription factors and gene regulatory networks …

The rete ovarii (RO) is an epithelial structure that arises during fetal development in close
proximity to the ovary and persists throughout adulthood in mice. However, the functional …

Introduction Neurons transport mRNA and translational machinery to axons for local
translation. After spinal cord injury (SCI), de novo translation is assumed to enable …

Diabetes ultimately results from an inadequate number of functional, insulin-producing
human beta cells. Although current attempts to replenish the remaining beta cell pool in …