[HTML][HTML] Mechanisms of action of fluvoxamine for COVID-19: a historical review
Y Hashimoto, T Suzuki, K Hashimoto - Molecular psychiatry, 2022 - nature.com
The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by the novel severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) accelerates the discovery of …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) accelerates the discovery of …
[HTML][HTML] Repurposing of CNS drugs to treat COVID-19 infection: targeting the sigma-1 receptor
K Hashimoto - European archives of psychiatry and clinical …, 2021 - Springer
The novel coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). The escalating number of SARS-CoV-2-infected …
syndrome coronavirus 2 (SARS-CoV-2). The escalating number of SARS-CoV-2-infected …
The sigma-1 receptor as a pluripotent modulator in living systems
The sigma-1 receptor (Sig-1R) is an endoplasmic reticulum (ER) protein that resides
specifically in the mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) …
specifically in the mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) …
The sigma-1 receptor: roles in neuronal plasticity and disease
Sigma-1 receptors (Sig-1Rs) have been implicated in many neurological and psychiatric
conditions. Sig-1Rs are intracellular chaperones that reside specifically at the endoplasmic …
conditions. Sig-1Rs are intracellular chaperones that reside specifically at the endoplasmic …
Sigma receptors [σ Rs]: biology in normal and diseased states
CG Rousseaux, SF Greene - Journal of Receptors and Signal …, 2016 - Taylor & Francis
This review compares the biological and physiological function of Sigma receptors [σRs] and
their potential therapeutic roles. Sigma receptors are widespread in the central nervous …
their potential therapeutic roles. Sigma receptors are widespread in the central nervous …
[HTML][HTML] Sigmar1's molecular, cellular, and biological functions in regulating cellular pathophysiology
The Sigma 1 receptor (Sigmar1) is a ubiquitously expressed multifunctional inter-organelle
signaling chaperone protein playing a diverse role in cellular survival. Recessive mutation in …
signaling chaperone protein playing a diverse role in cellular survival. Recessive mutation in …
Small molecules selectively targeting sigma-1 receptor for the treatment of neurological diseases
The sigma-1 (σ1) receptor, an enigmatic protein originally classified as an opioid receptor
subtype, is now understood to possess unique structural and functional features of its own …
subtype, is now understood to possess unique structural and functional features of its own …
Sigma-1 receptor chaperone and brain-derived neurotrophic factor: emerging links between cardiovascular disease and depression
K Hashimoto - Progress in neurobiology, 2013 - Elsevier
Epidemiological studies have demonstrated a close relationship between depression and
cardiovascular disease (CVD). Although it is known that the central nervous system (CNS) …
cardiovascular disease (CVD). Although it is known that the central nervous system (CNS) …
The role of sigma-1 receptor, an intracellular chaperone in neurodegenerative diseases
B Penke, L Fulop, M Szucs… - Current …, 2018 - ingentaconnect.com
Background: Widespread protein aggregation occurs in the living system under stress or
during aging, owing to disturbance of endoplasmic reticulum (ER) proteostasis. Many …
during aging, owing to disturbance of endoplasmic reticulum (ER) proteostasis. Many …
[HTML][HTML] Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor
M Rodríguez-Muñoz, Y Onetti, E Cortés-Montero… - Molecular brain, 2018 - Springer
Cannabidiol (CBD), the major non-psychotomimetic compound present in the Cannabis
sativa plant, exhibits therapeutic potential for various human diseases, including chronic …
sativa plant, exhibits therapeutic potential for various human diseases, including chronic …