Very-long-chain fatty acids induce glial-derived sphingosine-1-phosphate synthesis, secretion, and neuroinflammation

H Chung, Q Ye, YJ Park, Z Zuo, JW Mok, O Kanca… - Cell metabolism, 2023 - cell.com
VLCFAs (very-long-chain fatty acids) are the most abundant fatty acids in myelin. Hence,
during demyelination or aging, glia are exposed to higher levels of VLCFA than normal. We …

[HTML][HTML] More than mortar: glia as architects of nervous system development and disease

I Lago-Baldaia, VM Fernandes… - Frontiers in Cell and …, 2020 - frontiersin.org
Glial cells are an essential component of the nervous system of vertebrates and
invertebrates. In the human brain, glia are as numerous as neurons, yet the importance of …

The concept of neuroglia

A Verkhratsky, MS Ho, R Zorec, V Parpura - Neuroglia in …, 2019 - Springer
Neuroglia represent a diverse population of non-neuronal cells in the nervous systems, be
that peripheral, central, enteric or autonomic nervous system. Arguably, these cells …

[HTML][HTML] Drosophila ßHeavy-Spectrin is required in polarized ensheathing glia that form a diffusion-barrier around the neuropil

N Pogodalla, H Kranenburg, S Rey… - Nature …, 2021 - nature.com
In the central nervous system (CNS), functional tasks are often allocated to distinct
compartments. This is also evident in the Drosophila CNS where synapses and dendrites …

Ensheathing glia promote increased lifespan and healthy brain aging

L Sheng, EJ Shields, J Gospocic, M Sorida, L Ju… - Aging …, 2023 - Wiley Online Library
Glia have an emergent role in brain aging and disease. In the Drosophila melanogaster
brain, ensheathing glia function as phagocytic cells and respond to acute neuronal damage …

[HTML][HTML] Gliotransmission of D-serine promotes thirst-directed behaviors in Drosophila

A Park, V Croset, N Otto, D Agarwal, CD Treiber… - Current Biology, 2022 - cell.com
Thirst emerges from a range of cellular changes that ultimately motivate an animal to
consume water. Although thirst-responsive neuronal signals have been reported, the full …

Allometric analysis of brain cell number in Hymenoptera suggests ant brains diverge from general trends

RK Godfrey, M Swartzlander… - Proceedings of the …, 2021 - royalsocietypublishing.org
Many comparative neurobiological studies seek to connect sensory or behavioural attributes
across taxa with differences in their brain composition. Recent studies in vertebrates suggest …

[HTML][HTML] Polyploidy in the adult Drosophila brain

S Nandakumar, O Grushko, LA Buttitta - Elife, 2020 - elifesciences.org
Long-lived cells such as terminally differentiated postmitotic neurons and glia must cope
with the accumulation of damage over the course of an animal's lifespan. How long-lived …

[HTML][HTML] A role for glia in cellular and systemic metabolism: insights from the fly

JF De Backer, ICG Kadow - Current Opinion in Insect Science, 2022 - Elsevier
Highlights•Drosophila glia share many properties with their mammalian
counterparts.•Different subpopulations of glia cells cooperate to support neuronal energy …

Social reprogramming in ants induces longevity-associated glia remodeling

L Sheng, EJ Shields, J Gospocic, KM Glastad… - Science …, 2020 - science.org
In social insects, workers and queens arise from the same genome but display profound
differences in behavior and longevity. In Harpegnathos saltator ants, adult workers can …