Very-long-chain fatty acids induce glial-derived sphingosine-1-phosphate synthesis, secretion, and neuroinflammation
VLCFAs (very-long-chain fatty acids) are the most abundant fatty acids in myelin. Hence,
during demyelination or aging, glia are exposed to higher levels of VLCFA than normal. We …
during demyelination or aging, glia are exposed to higher levels of VLCFA than normal. We …
[HTML][HTML] More than mortar: glia as architects of nervous system development and disease
I Lago-Baldaia, VM Fernandes… - Frontiers in Cell and …, 2020 - frontiersin.org
Glial cells are an essential component of the nervous system of vertebrates and
invertebrates. In the human brain, glia are as numerous as neurons, yet the importance of …
invertebrates. In the human brain, glia are as numerous as neurons, yet the importance of …
The concept of neuroglia
Neuroglia represent a diverse population of non-neuronal cells in the nervous systems, be
that peripheral, central, enteric or autonomic nervous system. Arguably, these cells …
that peripheral, central, enteric or autonomic nervous system. Arguably, these cells …
[HTML][HTML] Drosophila ßHeavy-Spectrin is required in polarized ensheathing glia that form a diffusion-barrier around the neuropil
N Pogodalla, H Kranenburg, S Rey… - Nature …, 2021 - nature.com
In the central nervous system (CNS), functional tasks are often allocated to distinct
compartments. This is also evident in the Drosophila CNS where synapses and dendrites …
compartments. This is also evident in the Drosophila CNS where synapses and dendrites …
Ensheathing glia promote increased lifespan and healthy brain aging
Glia have an emergent role in brain aging and disease. In the Drosophila melanogaster
brain, ensheathing glia function as phagocytic cells and respond to acute neuronal damage …
brain, ensheathing glia function as phagocytic cells and respond to acute neuronal damage …
[HTML][HTML] Gliotransmission of D-serine promotes thirst-directed behaviors in Drosophila
Thirst emerges from a range of cellular changes that ultimately motivate an animal to
consume water. Although thirst-responsive neuronal signals have been reported, the full …
consume water. Although thirst-responsive neuronal signals have been reported, the full …
Allometric analysis of brain cell number in Hymenoptera suggests ant brains diverge from general trends
RK Godfrey, M Swartzlander… - Proceedings of the …, 2021 - royalsocietypublishing.org
Many comparative neurobiological studies seek to connect sensory or behavioural attributes
across taxa with differences in their brain composition. Recent studies in vertebrates suggest …
across taxa with differences in their brain composition. Recent studies in vertebrates suggest …
[HTML][HTML] Polyploidy in the adult Drosophila brain
S Nandakumar, O Grushko, LA Buttitta - Elife, 2020 - elifesciences.org
Long-lived cells such as terminally differentiated postmitotic neurons and glia must cope
with the accumulation of damage over the course of an animal's lifespan. How long-lived …
with the accumulation of damage over the course of an animal's lifespan. How long-lived …
[HTML][HTML] A role for glia in cellular and systemic metabolism: insights from the fly
JF De Backer, ICG Kadow - Current Opinion in Insect Science, 2022 - Elsevier
Highlights•Drosophila glia share many properties with their mammalian
counterparts.•Different subpopulations of glia cells cooperate to support neuronal energy …
counterparts.•Different subpopulations of glia cells cooperate to support neuronal energy …
Social reprogramming in ants induces longevity-associated glia remodeling
L Sheng, EJ Shields, J Gospocic, KM Glastad… - Science …, 2020 - science.org
In social insects, workers and queens arise from the same genome but display profound
differences in behavior and longevity. In Harpegnathos saltator ants, adult workers can …
differences in behavior and longevity. In Harpegnathos saltator ants, adult workers can …