Microbial production of advanced biofuels
Concerns over climate change have necessitated a rethinking of our transportation
infrastructure. One possible alternative to carbon-polluting fossil fuels is biofuels produced …
infrastructure. One possible alternative to carbon-polluting fossil fuels is biofuels produced …
Triptolide: reflections on two decades of research and prospects for the future
Covering: 2000 to 2020 Triptolide is a bioactive diterpene triepoxide isolated from
Tripterygium wilfordii Hook F, a traditional Chinese medicinal plant whose extracts have …
Tripterygium wilfordii Hook F, a traditional Chinese medicinal plant whose extracts have …
Engineering yeast for high-level production of diterpenoid sclareol
The diterpenoid sclareol is an industrially important precursor for alternative sustainable
supply of ambergris. However, its current production from plant extraction is neither …
supply of ambergris. However, its current production from plant extraction is neither …
Applications of synthetic biology in medical and pharmaceutical fields
X Yan, X Liu, C Zhao, GQ Chen - Signal transduction and targeted …, 2023 - nature.com
Synthetic biology aims to design or assemble existing bioparts or bio-components for useful
bioproperties. During the past decades, progresses have been made to build delicate …
bioproperties. During the past decades, progresses have been made to build delicate …
[HTML][HTML] Triptolide: pharmacological spectrum, biosynthesis, chemical synthesis and derivatives
J Gao, Y Zhang, X Liu, X Wu, L Huang, W Gao - Theranostics, 2021 - ncbi.nlm.nih.gov
Triptolide, an abietane-type diterpenoid isolated from Tripterygium wilfordii Hook. F., has
significant pharmacological activity. Research results show that triptolide has obvious …
significant pharmacological activity. Research results show that triptolide has obvious …
Synthetic biology-inspired cell engineering in diagnosis, treatment, and drug development
N Zhao, Y Song, X Xie, Z Zhu, C Duan… - … and Targeted Therapy, 2023 - nature.com
The fast-developing synthetic biology (SB) has provided many genetic tools to reprogram
and engineer cells for improved performance, novel functions, and diverse applications …
and engineer cells for improved performance, novel functions, and diverse applications …
Advances in developing metabolically engineered microbial platforms to produce fourth-generation biofuels and high-value biochemicals
Producing bio-based chemicals is imperative to establish an eco-friendly circular
bioeconomy. However, the compromised titer of these biochemicals hampers their …
bioeconomy. However, the compromised titer of these biochemicals hampers their …
Biosynthesis, total synthesis, and pharmacological activities of aryltetralin-type lignan podophyllotoxin and its derivatives
S Shen, Y Tong, Y Luo, L Huang, W Gao - Natural product reports, 2022 - pubs.rsc.org
Covering: up to 2022 Podophyllotoxin (PTOX, 1), a kind of aryltetralin-type lignan, was first
discovered in the plant Podophyllum peltatum and its structure was clarified by W. Borsche …
discovered in the plant Podophyllum peltatum and its structure was clarified by W. Borsche …
Recent progress and new perspectives for diterpenoid biosynthesis in medicinal plants
Z Hu, X Liu, M Tian, Y Ma, B Jin, W Gao… - Medicinal Research …, 2021 - Wiley Online Library
Abstract Diterpenoids, including more than 18,000 compounds, represent an important class
of metabolites that encompass both phytohormones and some industrially relevant …
of metabolites that encompass both phytohormones and some industrially relevant …
Tandemly duplicated CYP82Ds catalyze 14-hydroxylation in triptolide biosynthesis and precursor production in Saccharomyces cerevisiae
Y Zhang, J Gao, L Ma, L Tu, T Hu, X Wu, P Su… - Nature …, 2023 - nature.com
Triptolide is a valuable multipotent antitumor diterpenoid in Tripterygium wilfordii, and its C-
14 hydroxyl group is often selected for modification to enhance both the bioavailability and …
14 hydroxyl group is often selected for modification to enhance both the bioavailability and …