Microbial production of advanced biofuels

J Keasling, H Garcia Martin, TS Lee… - Nature Reviews …, 2021 - nature.com
Concerns over climate change have necessitated a rethinking of our transportation
infrastructure. One possible alternative to carbon-polluting fossil fuels is biofuels produced …

Triptolide: reflections on two decades of research and prospects for the future

L Tong, Q Zhao, E Datan, GQ Lin, I Minn… - Natural product …, 2021 - pubs.rsc.org
Covering: 2000 to 2020 Triptolide is a bioactive diterpene triepoxide isolated from
Tripterygium wilfordii Hook F, a traditional Chinese medicinal plant whose extracts have …

Engineering yeast for high-level production of diterpenoid sclareol

X Cao, W Yu, Y Chen, S Yang, ZK Zhao, J Nielsen… - Metabolic …, 2023 - Elsevier
The diterpenoid sclareol is an industrially important precursor for alternative sustainable
supply of ambergris. However, its current production from plant extraction is neither …

Applications of synthetic biology in medical and pharmaceutical fields

X Yan, X Liu, C Zhao, GQ Chen - Signal transduction and targeted …, 2023 - nature.com
Synthetic biology aims to design or assemble existing bioparts or bio-components for useful
bioproperties. During the past decades, progresses have been made to build delicate …

[HTML][HTML] Triptolide: pharmacological spectrum, biosynthesis, chemical synthesis and derivatives

J Gao, Y Zhang, X Liu, X Wu, L Huang, W Gao - Theranostics, 2021 - ncbi.nlm.nih.gov
Triptolide, an abietane-type diterpenoid isolated from Tripterygium wilfordii Hook. F., has
significant pharmacological activity. Research results show that triptolide has obvious …

Synthetic biology-inspired cell engineering in diagnosis, treatment, and drug development

N Zhao, Y Song, X Xie, Z Zhu, C Duan… - … and Targeted Therapy, 2023 - nature.com
The fast-developing synthetic biology (SB) has provided many genetic tools to reprogram
and engineer cells for improved performance, novel functions, and diverse applications …

Advances in developing metabolically engineered microbial platforms to produce fourth-generation biofuels and high-value biochemicals

MA Mehmood, A Shahid, S Malik, N Wang… - Bioresource …, 2021 - Elsevier
Producing bio-based chemicals is imperative to establish an eco-friendly circular
bioeconomy. However, the compromised titer of these biochemicals hampers their …

Biosynthesis, total synthesis, and pharmacological activities of aryltetralin-type lignan podophyllotoxin and its derivatives

S Shen, Y Tong, Y Luo, L Huang, W Gao - Natural product reports, 2022 - pubs.rsc.org
Covering: up to 2022 Podophyllotoxin (PTOX, 1), a kind of aryltetralin-type lignan, was first
discovered in the plant Podophyllum peltatum and its structure was clarified by W. Borsche …

Recent progress and new perspectives for diterpenoid biosynthesis in medicinal plants

Z Hu, X Liu, M Tian, Y Ma, B Jin, W Gao… - Medicinal Research …, 2021 - Wiley Online Library
Abstract Diterpenoids, including more than 18,000 compounds, represent an important class
of metabolites that encompass both phytohormones and some industrially relevant …

Tandemly duplicated CYP82Ds catalyze 14-hydroxylation in triptolide biosynthesis and precursor production in Saccharomyces cerevisiae

Y Zhang, J Gao, L Ma, L Tu, T Hu, X Wu, P Su… - Nature …, 2023 - nature.com
Triptolide is a valuable multipotent antitumor diterpenoid in Tripterygium wilfordii, and its C-
14 hydroxyl group is often selected for modification to enhance both the bioavailability and …