Plants in anticancer drug discovery: from molecular mechanism to chemoprevention

AJ Siddiqui, S Jahan, R Singh, J Saxena… - BioMed Research …, 2022 - Wiley Online Library
Cancer is one of the primary causes of mortality globally, and the discovery of new
anticancer drugs is the most important need in recent times. Natural products have been …

Caffeic acid and its derivatives as potential modulators of oncogenic molecular pathways: New hope in the fight against cancer

S Mirzaei, MH Gholami, A Zabolian, H Saleki… - Pharmacological …, 2021 - Elsevier
As a phenolic acid compound, caffeic acid (CA) can be isolated from different sources such
as tea, wine and coffee. Caffeic acid phenethyl ester (CAPE) is naturally occurring derivative …

Multidrug resistance of cancer cells and the vital role of P-glycoprotein

C Karthika, R Sureshkumar, M Zehravi, R Akter, F Ali… - Life, 2022 - mdpi.com
P-glycoprotein (P-gp) is a major factor in the multidrug resistance phenotype in cancer cells.
P-gp is a protein that regulates the ATP-dependent efflux of a wide range of anticancer …

Recent progress in functionalized and targeted polymersomes and chimeric polymeric nanotheranostic platforms for cancer therapy

M Beygi, F Oroojalian, SS Hosseini… - Progress in Materials …, 2023 - Elsevier
The majority of advances in cancer therapy have been achieved based on developments in
public awareness, as well as novel diagnostic and therapeutic modalities. Treatment …

Coumarins as fungal metabolites with potential medicinal properties

OM Tsivileva, OV Koftin, NV Evseeva - Antibiotics, 2022 - mdpi.com
Coumarins are a structurally varied set of 2 H-chromen-2-one compounds categorized also
as members of the benzopyrone group of secondary metabolites. Coumarin derivatives …

[HTML][HTML] Modulatory effect of caffeic acid in alleviating diabetes and associated complications

R Ganguly, SV Singh, K Jaiswal, R Kumar… - World Journal of …, 2023 - ncbi.nlm.nih.gov
Diabetes mellitus (DM) is one of the most common metabolic disorders characterized by
elevated blood glucose levels. Prolonged uncontrolled hyperglycemia often leads to multi …

[HTML][HTML] Phytochemical based nanomedicine: a panacea for cancer treatment, present status and future prospective

P Mohapatra, P Singh, D Singh, S Sahoo, SK Sahoo - OpenNano, 2022 - Elsevier
Cancer is one of the leading causes of mortality worldwide. Currently available anticancer
therapeutic strategies are not able to improve the survival rate of patients over the past few …

In vitro toxicity of naringin and berberine alone, and encapsulated within PMMA nanoparticles

J Secerli, Ş Adatepe, S Altuntas, GR Topal, O Erdem… - Toxicology in Vitro, 2023 - Elsevier
Phytochemical compounds, such as naringin and berberine, have been used for many years
due to their antioxidant activities, and consequently, beneficial health effects. In this study, it …

A review of nanomaterials from synthetic and natural molecules for prospective breast cancer nanotherapy

P Kumar, B Mangla, S Javed, W Ahsan… - Frontiers in …, 2023 - frontiersin.org
Breast cancer being one of the most frequent cancers in women accounts for almost a
quarter of all cancer cases. Early and late-stage breast cancer outcomes have improved …

Phytochemicals mediated modulation of microRNAs and long non‐coding RNAs in cancer prevention and therapy

LM Ruiz‐Manriquez, C Estrada‐Meza… - Phytotherapy …, 2022 - Wiley Online Library
MicroRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are two main categories of
noncoding RNAs (ncRNAs) that can influence essential biological functions in various ways …