Antimicrobial resistance: two-component regulatory systems and multidrug efflux pumps

GV De Gaetano, G Lentini, A Famà, F Coppolino… - Antibiotics, 2023 - mdpi.com
The number of multidrug-resistant bacteria is rapidly spreading worldwide. Among the
various mechanisms determining resistance to antimicrobial agents, multidrug efflux pumps …

Current state and novel outlook on prevention and treatment of rising antibiotic resistance in urinary tract infections

EK Sher, A Džidić-Krivić, A Sesar, EK Farhat… - Pharmacology & …, 2024 - Elsevier
Antibiotic-resistant bacteria are currently an important public health concern posing a
serious threat due to their resistance to the current arsenal of antibiotics. Uropathogens …

Enzyme Production and Inhibitory Potential of Pseudomonas aeruginosa: Contrasting Clinical and Environmental Isolates

H Aqel, N Sannan, R Foudah, A Al-Hunaiti - Antibiotics, 2023 - mdpi.com
(1) Background: This study summarizes the findings of two studies investigating the
inhibitory effects of Pseudomonas aeruginosa strains from clinical and environmental …

The SaeRS two-component system regulates virulence gene expression in group B Streptococcus during invasive infection

F Coppolino, GV De Gaetano, C Claverie, O Sismeiro… - Mbio, 2024 - journals.asm.org
ABSTRACT Group B Streptococcus (GBS) is a pathobiont responsible for invasive infections
in neonates and the elderly. The transition from a commensal to an invasive pathogen relies …

Hyperphosphorylation of the group A streptococcal control of virulence regulator increases promoter occupancy specifically at virulence factor-encoding genes

N Horstmann, CN Tran, AR Flores… - Journal of …, 2023 - Am Soc Microbiol
The c ontrol ofv irulence two-component gene regulatory system (CovRS) is critical to the
pathogenesis of many medically important streptococci. In emm1 group A streptococci …

Investigating the interaction of zno nanoparticles with flagellum and fimbriae in multi-drug resistant uropathogenic bacteria encoding fli and fim genes

MB Mohammadgholi Pour, M Doudi, AM Ahadi… - Brazilian Journal of …, 2024 - Springer
Due to the increasing occurrence of drug resistant urinary tract infections (UTI) among
children, there is a need to investigate alternative effective treatment protocols such as …

PbsP, a major virulence factor of Streptococcus agalactiae, is regulated by the SaeRS two-component system

F Coppolino - 2024 - tesidottorato.depositolegale.it
Two-component regulatory systems (TCSs) are signal transduction machineries commonly
used by prokaryotes to sense and respond to environmental conditions by modifying gene …

Bacterial Profile and Evaluation of Cxcl10 Level in Urine Among People Suffering from Urinary Tract Infections

AA Abdulhussein, M Aljilawi… - Karbala Journal of …, 2024 - journals.uokerbala.edu.iq
A common bacterial infection that affects millions of people worldwide every year are
infections of the urinary tract. The most frequent causes of urinary tract infections, both …