Brain function critically depends on a close matching between metabolic demands,
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …

Background—Age-related dementia, most commonly caused by Alzheimer disease or
cerebrovascular factors (vascular dementia), is a major public health threat. Chronic arterial …

The precise regulation of cerebral blood flow is critical for normal brain function, and its
disruption underlies many neuropathologies. The extent to which smooth muscle-covered …

Cognitive function is an important component of aging and predicts quality of life, functional
independence, and risk of institutionalization. Advances in our understanding of the role of …

Vascular cognitive impairment defines alterations in cognition, ranging from subtle deficits to
full-blown dementia, attributable to cerebrovascular causes. Often coexisting with …

The consequences of cerebrovascular disease are among the leading health issues
worldwide. Large and small cerebral vessel disease can trigger stroke and contribute to the …

Maintenance of brain function depends on a constant blood supply. Deficits in cerebral
blood flow are linked to cognitive decline, and they have detrimental effects on the outcome …

The brain is highly dependent on an adequate delivery of oxygen and glucose from the
circulation, and cerebral blood flow (CBF) reductions impair neuronal function and, if …

Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow
limitation and loss of lung function, and is currently the third largest cause of death in the …

Vascular contributions to cognitive impairment are receiving heightened attention as
potentially modifiable factors for dementias of later life. These factors have now been linked …