Traumatic spinal cord injury: an overview of pathophysiology, models and acute injury mechanisms

A Alizadeh, SM Dyck, S Karimi-Abdolrezaee - Frontiers in neurology, 2019 - frontiersin.org
Traumatic spinal cord injury (SCI) is a life changing neurological condition with substantial
socioeconomic implications for patients and their care-givers. Recent advances in medical …

Spinal cord injury models: a review

T Cheriyan, DJ Ryan, JH Weinreb, J Cheriyan, JC Paul… - Spinal cord, 2014 - nature.com
Background: Animal spinal cord injury (SCI) models have proved invaluable in better
understanding the mechanisms involved in traumatic SCI and evaluating the effectiveness of …

Spinal-cord injury

JW McDonald, C Sadowsky - The Lancet, 2002 - thelancet.com
More than a decade ago, spinal-cord injury meant confinement to a wheelchair and a
lifetime of medical comorbidity. The physician's armamentarium of treatments was very …

Five basic muscle activation patterns account for muscle activity during human locomotion

YP Ivanenko, RE Poppele… - The Journal of …, 2004 - Wiley Online Library
An electromyographic (EMG) activity pattern for individual muscles in the gait cycle exhibits
a great deal of intersubject, intermuscle and context‐dependent variability. Here we …

Spinal shock revisited: a four-phase model

JF Ditunno, JW Little, A Tessler, AS Burns - Spinal cord, 2004 - nature.com
Spinal shock has been of interest to clinicians for over two centuries. Advances in our
understanding of both the neurophysiology of the spinal cord and neuroplasticity following …

Plasticity of the spinal neural circuitry after injury

VR Edgerton, NJK Tillakaratne, AJ Bigbee… - Annu. Rev …, 2004 - annualreviews.org
▪ Abstract Motor function is severely disrupted following spinal cord injury (SCI). The spinal
circuitry, however, exhibits a great degree of automaticity and plasticity after an injury …

Mechanisms underlying the neuromodulation of spinal circuits for correcting gait and balance deficits after spinal cord injury

EM Moraud, M Capogrosso, E Formento, N Wenger… - Neuron, 2016 - cell.com
Epidural electrical stimulation of lumbar segments facilitates standing and walking in animal
models and humans with spinal cord injury. However, the mechanisms through which this …

[HTML][HTML] Extracellular stimulation of central neurons: influence of stimulus waveform and frequency on neuronal output

CC McIntyre, WM Grill - Journal of neurophysiology, 2002 - journals.physiology.org
The objective of this project was to examine the influence of stimulus waveform and
frequency on extracellular stimulation of neurons with their cell bodies near the electrode …

License to run: exercise impacts functional plasticity in the intact and injured central nervous system by using neurotrophins

S Vaynman, F Gomez-Pinilla - … and neural repair, 2005 - journals.sagepub.com
Exercise has been found to impact molecular systems important for maintaining neural
function and plasticity. A characteristic finding for the effects of exercise in the brain and …

Kinematic design to improve ergonomics in human machine interaction

A Schiele, FCT Van Der Helm - IEEE Transactions on neural …, 2006 - ieeexplore.ieee.org
This paper introduces a novel kinematic design paradigm for ergonomic human machine
interaction. Goals for optimal design are formulated generically and applied to the …