Neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease and
Huntington's disease, present a major health issue and financial burden for health care …

Alzheimer's Disease (AD) is a devastating neurodegenerative disorder of the brain, clinically
characterised by cognitive deficits that gradually worsen over time. There is, at present, no …

Type 2 diabetes is a risk factor for Alzheimer's disease, most likely linked to an impairment of
insulin signaling in the brain. The incretin hormone glucagon-like peptide-1 (GLP-1) …

The synapse has consistently been considered a vulnerable and critical target within
Alzheimer's disease, and synapse loss is, to date, one of the main biological correlates of …

Type 2 diabetes is a risk factor in the development of Alzheimer's disease (AD). It has been
shown that insulin signalling is desensitised in the brains of AD patients. The incretin …

Dysregulation of histone acetylation has been implicated in the onset of age-associated
memory impairment and the pathogenesis of neurodegenerative diseases. Elevation of …

Alzheimer's disease (AD) affects an estimated 5.8 million Americans, and advanced age is
the greatest risk factor. AD patients have altered intestinal microbiota. Accordingly, depleting …

Physical exercise is considered to exert a positive neurophysiological effect that helps to
maintain normal brain activity in the elderly. Expectations that it could help to fight …

Aging is an important factor in memory decline in aged animals and humans and in
Alzheimer's disease and is associated with the impairment of hippocampal long-term …

Brain-derived neurotrophic factor (BDNF) is actively produced and utilized in cortical circuits
throughout life to sustain neuronal function and synaptic plasticity. In animal models of …