Ectonucleotidases modulate inflammatory responses by balancing extracellular ATP and
adenosine (ADO) and might be involved in COVID-19 immunopathogenesis. Here, we …

Mitochondria are the source of damage-associated molecular patterns (DAMPs), which are
molecules that play a key modulatory role in immune cells. These molecules include …

In the last decade, three-dimensional (3D) cell culture technology has gained a lot of interest
due to its ability to better recapitulate the in vivo organization and microenvironment of in …

Ectonucleotidases are extracellular enzymes with a pivotal role in inflammation that
hydrolyse extracellular purine and pyrimidine nucleotides, eg, ATP, UTP, ADP, UDP, AMP …

Extracellular purinergic molecules act as signaling molecules that bind to cellular receptors
and regulate signaling pathways. Growing evidence suggests that purines regulate …

Adenosine (Ado) has been shown to have immunosuppressive effects in a variety of
diseases. It can either be released directly into the extracellular environment by cells, or it …

Organs and tissues and their constituent cells are physiologically submitted to diverse types
of mechanical forces or stress, one common sequence of which is release of intracellular …

Overcoming refractory epilepsy's resistance to the combination of antiepileptic drugs (AED),
mitigating side effects, and preventing sudden unexpected death in epilepsy are critical …

T cells must migrate to encounter antigen-presenting cells and perform their roles in host
defense. Here, we found that autocrine stimulation of the purinergic receptor P2Y11 …

BACKGROUND: 3′, 5′-cyclic AMP (cAMP) regulates numerous cardiac functions. Various
hormones and neurotransmitters elevate intracellular cAMP (i [cAMP]) in cardiomyocytes …