Purinergic signaling through adenosine plays a key role in immune regulation. Hypoxia-
driven accumulation of extracellular adenosine results in the generation of an …

Psoriasis is a chronic inflammatory disease of the skin associated with systemic and joint
manifestations and accompanied by comorbidities, such as metabolic syndrome and …

Inflammation triggered by metabolic imbalance, also called metainflammation, is low-grade
inflammation caused by the components involved in metabolic syndrome (MetS), including …

Body tissues are exposed to a complex mechanical environment, which is perceived by cells
and converted to biochemical signals such as ATP release. We performed a meta-analysis …

Taste buds are the sensory end organs for gustation, mediating sensations of salty, sour,
bitter, sweet and umami as well as other possible modalities, for example, fat and kokumi …

The lytic release of ATP due to cell and tissue injury constitutes an important source of
extracellular nucleotides and may have physiological and pathophysiological roles by …

Trigeminal ganglion (TG) is the first station of sensory pathways in the orofacial region. The
TG neurons communicate with satellite glial cells (SGCs), macrophages and other cells …

Two types of anion channels are directly activated by osmotic swelling and are involved in
the regulatory volume decrease (RVD) in most types of mammalian cells, and they include …

An increasing number of studies have demonstrated the significant roles of the interplay
between microenvironmental mechanics in tissues and biochemical-genetic activities in …

Membrane ion channels of the calcium homeostasis modulator (CALHM) family promote cell–
cell crosstalk at neuronal synapses via ATP release, where ATP acts as a neurotransmitter …