Myocardial remodelling is a molecular, cellular, and interstitial adaptation of the heart in
response to altered environmental demands. The heart undergoes reversible physiological …

Since their discovery in the 1970s, purinergic receptors have been shown to play key roles
in a wide variety of biologic systems and cell types. In the immune system, purinergic …

Environmental allergens that interact with the airway epithelium can activate cellular stress
pathways that lead to the release of danger signals known as alarmins. The mechanisms of …

ABSTRACT Pannexin 1 (PANX1) channel is a critical ATP-releasing pathway that modulates
tumor immunity, progression, and prognosis. However, the roles of PANX1 in different …

An efficient harvest of hematopoietic stem/progenitor cells (HSPCs) after pharmacological
mobilization from the bone marrow (BM) into peripheral blood (PB) and subsequent proper …

Following activation, CD8 T cells transition from reliance on mitochondrial respiration to
increasing utilization of aerobic glycolysis. After the effector phase, however, reversion to …

Abstract Development of autosomal dominant polycystic kidney disease (ADPKD) involves
renal epithelial cell abnormalities. Cystic fluid contains a high level of ATP that, among other …

An elaborate volume regulation system based on interplay of ion channels and transporters
was evolved to cope with constant osmotic challenges caused by intensive metabolism …

Urgency urinary incontinence (UUI) and overactive bladder (OAB) can both potentially be
influenced by commensal and urinary tract infection-associated bacteria. The sensing of …

Skeletal system is a highly dynamic system going through continuous resorption and
reconstruction to maintain homeostasis, which is influenced by numerous factors. Once the …