Genetic predisposition is necessary for polycystic kidney disease (PKD) initiation, although
there are other, incompletely identified downstream processes that are required for cyst …

Extracellular ATP is a potent signaling molecule released from various cells throughout the
body and is intimately involved in the pathophysiological functions of the nervous system …

Preclinical studies provided some important insights into the action of glucagon-like peptide
1 (GLP-1) in taste perception. This review examines the literature to uncover some …

Following peripheral nerve injury, extracellular adenosine 5′-triphosphate (ATP)–mediated
purinergic signaling is crucial for spinal cord microglia activation and neuropathic pain …

Intracellular Ca2+ dynamics shape malignant behaviors of cancer cells. Whereas previous
studies focused on cultured cancer cells, we here used breast organoids and colonic crypts …

Purines are nitrogen compounds consisting mainly of a nitrogen base of adenine (ABP) or
guanine (GBP) and their derivatives: nucleosides (nitrogen bases plus ribose) and …

Embryo implantation involves a sterile inflammatory reaction that is required for the invasion
of the blastocyst into the decidua. Adenosine triphosphate (ATP) released from stressed or …

The purinergic signaling has an important role in regulating pancreatic exocrine secretion.
The exocrine pancreas is also a site of one of the most serious cancer forms, the pancreatic …

Abstract Geoff Burnstock (1929–2020) discovered purinergic signaling in a fastidious
research that started in early 1960 and culminated in a concept of purinergic nerves in 1972 …

Abstract Background Astrocytes Ca2+ signaling play a central role in the modulation of
neuronal function. Activation of metabotropic glutamate receptors (mGluR) by glutamate …