Blood-based biomarkers for Alzheimer's disease: Current state and future use in a transformed global healthcare landscape
Timely detection of the pathophysiological changes and cognitive impairment caused by
Alzheimer's disease (AD) is increasingly pressing because of the advent of biomarker …
Alzheimer's disease (AD) is increasingly pressing because of the advent of biomarker …
The role of amyloid PET in imaging neurodegenerative disorders: a review
M Chapleau, L Iaccarino… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Imaging of amyloid deposition using PET has been available in research studies for 2
decades and has been approved for clinical use by the US Food and Drug Administration …
decades and has been approved for clinical use by the US Food and Drug Administration …
Overview of the blood biomarkers in Alzheimer's disease: promises and challenges
The increasing number of people with advanced Alzheimer's disease (AD) represents a
significant psychological and financial cost to the world population. Accurate detection of the …
significant psychological and financial cost to the world population. Accurate detection of the …
Clinical performance of an antibody-free assay for plasma Aβ42/Aβ40 to detect early alterations of Alzheimer's disease in individuals with subjective cognitive decline
M Pascual-Lucas, JA Allué, L Sarasa, N Fandos… - Alzheimer's Research & …, 2023 - Springer
Background Accessible and cost-effective diagnostic tools are urgently needed to accurately
quantify blood biomarkers to support early diagnosis of Alzheimer's disease (AD). In this …
quantify blood biomarkers to support early diagnosis of Alzheimer's disease (AD). In this …
Fully automated and highly specific plasma β-amyloid immunoassays predict β-amyloid status defined by amyloid positron emission tomography with high accuracy
K Yamashita, M Miura, S Watanabe, K Ishiki… - Alzheimer's Research & …, 2022 - Springer
Background Clinicians, researchers, and patients alike would greatly benefit from more
accessible and inexpensive biomarkers for neural β-amyloid (Aβ). We aimed to assess the …
accessible and inexpensive biomarkers for neural β-amyloid (Aβ). We aimed to assess the …
Alzheimer blood biomarkers: practical guidelines for study design, sample collection, processing, biobanking, measurement and result reporting
X Zeng, Y Chen, A Sehrawat, J Lee, TK Lafferty… - Molecular …, 2024 - Springer
Abstract Alzheimer's disease (AD), the most common form of dementia, remains challenging
to understand and treat despite decades of research and clinical investigation. This might be …
to understand and treat despite decades of research and clinical investigation. This might be …
[HTML][HTML] Distinct effects of blood pressure parameters on Alzheimer's and vascular markers in 1,952 Asian individuals without dementia
S Lee, SE Kim, H Jang, JP Kim, G Sohn… - … Research & Therapy, 2024 - ncbi.nlm.nih.gov
Background Risk factors for cardiovascular disease, including elevated blood pressure, are
known to increase risk of Alzheimer's disease. There has been increasing awareness of the …
known to increase risk of Alzheimer's disease. There has been increasing awareness of the …
Deep learning model for individualized trajectory prediction of clinical outcomes in mild cognitive impairment
Objectives Accurately predicting when patients with mild cognitive impairment (MCI) will
progress to dementia is a formidable challenge. This work aims to develop a predictive deep …
progress to dementia is a formidable challenge. This work aims to develop a predictive deep …
Fluid biomarkers in cerebral amyloid angiopathy
Cerebral amyloid angiopathy (CAA) is a type of cerebrovascular disorder characterised by
the accumulation of amyloid within the leptomeninges and small/medium-sized cerebral …
the accumulation of amyloid within the leptomeninges and small/medium-sized cerebral …
Emerging role of vascular burden in AT (N) classification in individuals with Alzheimer's and concomitant cerebrovascular burdens
Objectives Alzheimer's disease (AD) is characterised by amyloid-beta accumulation (A), tau
aggregation (T) and neurodegeneration (N). Vascular (V) burden has been found …
aggregation (T) and neurodegeneration (N). Vascular (V) burden has been found …