Mitochondria play important roles in energy generation and homeostasis maintenance in
eukaryotic cells. The damaged or superfluous mitochondria can be nonselectively or …

Amiodarone hydrochloride (AMD), an anti‐arrhythmic agent, has been shown to cause
peripheral neuropathy; however, its pathogenesis remains unknown. We examined the toxic …

Cystic Fibrosis (CF) due to the ΔF508 mutation of cystic fibrosis transmembrane
conductance regulator (CFTR) can be treated with a combination of cysteamine and …

'Foamy'alveolar macrophages (FAM) observed in nonclinical toxicology studies during
inhaled drug development may indicate drug-induced phospholipidosis, but can also derive …

In this study, we explored to detect the effects and mechanism of bone‐marrow‐derived
mesenchymal stem cells (BMSCs) on ventilator‐induced lung injury (VILI). We transplanted …

Amiodarone (AM) is an effective anti-arrhythmic drug. We investigated the role of mast cells
and macrophages on AM induced pulmonary fibrosis and the action of atorvastatin on this …

The antiarrhythmic agent amiodarone, a cationic amphiphilic drug, is known to induce
phospholipidosis, ie the accumulation of phospholipids within lysosomal structures to give …

摘要Amiodarone 為第三類抗心律不整藥, 在許多案例曾被報告很多副作用,
其中以肺毒性為最嚴重, 甚至可能併發急性呼吸窘迫症候群(acute respiratory distress …