Computational methods for detecting large-scale structural rearrangements in chromosomes
Large-scale structural chromosomal rearrangements or structural variants, such as
insertions, deletions, translocations, and inversions may result in the exchange of coding or …
insertions, deletions, translocations, and inversions may result in the exchange of coding or …
Statistical considerations on NGS data for inferring copy number variations
J Chen - Deep Sequencing Data Analysis, 2021 - Springer
The next-generation sequencing (NGS) technology has revolutionized research in genetics
and genomics, resulting in massive NGS data and opening more fronts to answer …
and genomics, resulting in massive NGS data and opening more fronts to answer …
A modified information criterion for tuning parameter selection in 1d fused LASSO for inference on multiple change points
J Lee, J Chen - Journal of Statistical Computation and Simulation, 2020 - Taylor & Francis
Inference about multiple change points has been an interesting topic in the statistics
literature. Recently, the high throughput technologies became the most popularly used tools …
literature. Recently, the high throughput technologies became the most popularly used tools …
A penalized regression approach for DNA copy number study using the sequencing data
J Lee, J Chen - Statistical Applications in Genetics and Molecular …, 2019 - degruyter.com
Modeling the high-throughput next generation sequencing (NGS) data, resulting from
experiments with the goal of profiling tumor and control samples for the study of DNA copy …
experiments with the goal of profiling tumor and control samples for the study of DNA copy …
Statistical models for DNA copy number variation detection using read‐depth data from next generation sequencing experiments
Summary In this 'Big Data'era, statisticians inevitably encounter data generated from various
disciplines. In particular, advances in bio‐technology have enabled scientists to produce …
disciplines. In particular, advances in bio‐technology have enabled scientists to produce …
X 染色体变异对男性精神发育迟滞致病性的研究进展
彭继苹， 刘芳， 谢华， 陈晓丽 - 遗传, 2017 - chinagene.cn
精神发育迟滞(旧称智力低下) 作为儿科神经科常见的一组疾患, 具有高度的遗传和表型异质性,
大约25%~ 50% 的精神发育迟滞是由遗传因素引起的, 其中X 染色体基因/基因组变异占25 …
大约25%~ 50% 的精神发育迟滞是由遗传因素引起的, 其中X 染色体基因/基因组变异占25 …
A statistical change-point analysis approach for modeling the ratio of next generation sequencing reads
J Chen, H Li - Advances in the Mathematical Sciences: Research …, 2016 - Springer
One of the key features of statistical change-point analysis is to estimate the unknown
change-point locations for various statistical models imposed on the sample data. This …
change-point locations for various statistical models imposed on the sample data. This …
Place du NGS (Next Generation Sequencing) et de l'ADN tumoral circulant dans le testing moléculaire des cancers bronchiques
N Pécuchet, A Legras, P Laurent-Puig, H Blons - Annales de pathologie, 2016 - Elsevier
Résumé Le diagnostic moléculaire joue aujourd'hui un rôle clé dans la prise en charge des
patients atteints de cancers au stade métastatique. Il est probable que le développement …
patients atteints de cancers au stade métastatique. Il est probable que le développement …