Neuroinflammation is involved in the onset or progression of various neurodegenerative
diseases. Initiation of neuroinflammation is triggered by endogenous substances (damage …

Traumatic brain injury (TBI) can have lifelong and dynamic effects on health and wellbeing.
Research on the long-term consequences emphasises that, for many patients, TBI should be …

The blood coagulation protein fibrinogen is deposited in the brain in a wide range of
neurological diseases and traumatic injuries with blood–brain barrier (BBB) disruption …

Vascular contributions to cognitive impairment and dementia (VCID) are characterized by
the aging neurovascular unit being confronted with and failing to cope with biological insults …

Traditionally seen as a sudden, brutal event with short-term impairment, traumatic brain
injury (TBI) may cause persistent, sometimes life-long, consequences. While mortality after …

The blood-brain barrier (BBB) is a major functional barrier in the central nervous system
(CNS), and inhibits the extravasation of intravascular contents and transports various …

Normal haemostasis depends on an intricate balance between mechanisms of bleeding and
mechanisms of thrombosis, and this balance can be altered after traumatic brain injury (TBI) …

Background The use of blood biomarkers after mild traumatic brain injury (mTBI) has been
widely studied. We have identified eight unresolved issues related to the use of five …

Aging involves a decline in neural function that contributes to cognitive impairment and
disease. However, the mechanisms underlying the transition from a young-and-healthy to …

The mechanisms underpinning concussion, traumatic brain injury, and chronic traumatic
encephalopathy, and the relationships between these disorders, are poorly understood. We …