Links between inflammatory bowel disease and chronic obstructive pulmonary disease

AL Raftery, E Tsantikos, NL Harris… - Frontiers in …, 2020 - frontiersin.org
Inflammatory bowel disease (IBD) and chronic obstructive pulmonary disease (COPD) are
chronic inflammatory diseases of the gastrointestinal and respiratory tracts, respectively …

Gut microbiota-produced tryptamine activates an epithelial G-protein-coupled receptor to increase colonic secretion

Y Bhattarai, BB Williams, EJ Battaglioli, WR Whitaker… - Cell host & …, 2018 - cell.com
Tryptamine, a tryptophan-derived monoamine similar to 5-hydroxytryptamine (5-HT), is
produced by gut bacteria and is abundant in human and rodent feces. However, the …

The aryl hydrocarbon receptor in the crossroad of signalling networks with therapeutic value

ÁC Roman, JM Carvajal-Gonzalez, JM Merino… - Pharmacology & …, 2018 - Elsevier
The aryl hydrocarbon receptor (AhR) is well-known for its major contributions to the cellular
responses against environmental toxins and carcinogens. Notably, AhR has also emerged …

Identification of gene expression profiles associated with an increased risk of post-operative recurrence in Crohn's disease

M Ngollo, K Perez, N Hammoudi… - Journal of Crohn's …, 2022 - academic.oup.com
Abstract Background and Aims Ileocolonic resection is frequently needed in the course of
Crohn's disease [CD] treatment and post-operative recurrence is extremely common. Our …

Epigenetic regulations of AhR in the aspect of immunomodulation

A Wajda, J Łapczuk-Romańska… - International Journal of …, 2020 - mdpi.com
Environmental factors contribute to autoimmune disease manifestation, and as regarded
today, AhR has become an important factor in studies of immunomodulation. Besides …

Evolution of hominin detoxification: Neanderthal and modern human Ah receptor respond similarly to TCDD

JM Aarts, GM Alink, HJ Franssen… - Molecular Biology and …, 2021 - academic.oup.com
In studies of hominin adaptations to fire use, the role of the aryl hydrocarbon receptor (AHR)
in the evolution of detoxification has been highlighted, including statements that the modern …

AHR gene expression and the polymorphism rs2066853 are associated with clinicopathological parameters in colorectal carcinoma

T Cheng, SMK Gamage, D Hewage, CT Lu, S Aktar… - Human Pathology, 2022 - Elsevier
The relationship between red and processed meat and its risk toward colorectal carcinoma
(CRC) is not fully explored in literature. Polycyclic aromatic hydrocarbons (PAHs) are …

Aryl hydrocarbon receptor polymorphisms are associated with dry skin phenotypes in Chinese patients with atopic dermatitis

ZZ Li, WL Zhong, H Hu, XF Chen… - Clinical and …, 2019 - academic.oup.com
Background Epidermal barrier dysfunction is the initial event in the development of atopic
dermatitis (AD). Recent studies have identified a crucial role for the aryl hydrocarbon …

Evaluation of variation in genes of the arylhydrocarbon receptor pathway for an association with multiple sclerosis

N Zorlu, S Hoffjan, A Haghikia, IV Deyneko… - Journal of …, 2019 - Elsevier
The aryl hydrocarbon receptor (AhR) contributes to immune regulation in autoimmune
diseases such as multiple sclerosis (MS). Analysis of selected polymorphisms in AhR …

Association of Crohn's disease with aryl hydrocarbon receptor gene polymorphisms in patients from Southeast China

C Wu, Q Lin, S Ying, J Luo, W Hong, Z Lin… - Immunological …, 2019 - Taylor & Francis
Aims The aryl hydrocarbon receptor (AhR) plays a pivotal role in regulating the innate and
the acquired immune systems. The present study aimed to investigate the association of …