Sepsis arises from diverse and incompletely understood dysregulated host response
processes following infection that leads to life-threatening organ dysfunction. Here we …

Sepsis is a common and deadly condition. Within the current model of sepsis
immunobiology, the framing of dysregulated host immune responses into proinflammatory …

Sepsis disproportionally affects children across all health-care settings and is one of the
leading causes of morbidity and mortality in neonatal and paediatric age groups. As shown …

Purpose The heterogeneity in sepsis is held responsible, in part, for the lack of precision
treatment. Many attempts to identify subtypes of sepsis patients identify those with shared …

Background Sepsis is a heterogenous syndrome with limited therapeutic options. Identifying
immunological endotypes through gene expression patterns in septic patients may lead to …

Diagnostics require precision and predictive ability to be clinically useful. Integration of multi-
omic with clinical data is crucial to our understanding of disease pathogenesis and …

Critical care uses syndromic definitions to describe patient groups for clinical practice and
research. There is growing recognition that a “precision medicine” approach is required and …

Background Multiple organ dysfunction syndrome (MODS) disproportionately drives
morbidity and mortality among critically ill patients. However, we lack a comprehensive …

Recent clinical and research efforts in cardiogenic shock (CS) have largely focussed on the
restoration of the low cardiac output state that is the conditio sine qua non of the clinical …

Molecular Pathways in Sepsis Pathogenesis: Recent Advances and Therapeutic Avenues
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