MicroRNAs (miRNAs) are crucial post-transcriptional regulators of haematopoietic cell fate
decisions. They act by negatively regulating the expression of key immune development …

Following periods of haematopoietic cell stress, such as after chemotherapy, radiotherapy,
infection and transplantation, patient outcomes are linked to the degree of immune …

Age-related clonal hematopoiesis (CH) is a risk factor for malignancy, cardiovascular
disease, and all-cause mortality. Somatic mutations in DNMT3A are drivers of CH, but …

The genetic, functional or compositional heterogeneity of healthy and diseased tissues
presents major challenges in drug discovery and development. Such heterogeneity hinders …

Classical and non-classical monocytes, and the macrophages and monocyte-derived
dendritic cells they produce, play key roles in host defense against pathogens, immune …

Atherosclerosis: the interplay between lipids and immune cel... : Current Opinion in Lipidology
Atherosclerosis: the interplay between lipids and immune cells : Current Opinion in Lipidology …

Chronic infections affect a third of the world's population and can cause bone marrow
suppression, a severe condition that increases mortality from infection. To uncover the basis …

Hematopoietic stem cells (HSCs) underlie the production of blood and immune cells for the
lifetime of an organism. In vertebrate embryos, HSCs arise from the unique …

Cardiac macrophages are abundant in the healthy heart and after myocardial infarction (MI).
Different macrophage phenotypes likely promote myocardial health vs. disease. Infarct …

Our understanding of mechanisms underlying progression from Mycobacterium tuberculosis
infection to pulmonary tuberculosis disease in humans remains limited. To define such …