T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

This Review discusses the major advances and changes made over the past 3 years to our
understanding of chimeric antigen receptor (CAR) T cell efficacy and safety. Recently, the …

Regulatory T cells (Treg cells) are a small subset of immune cells that are dedicated to
curbing excessive immune activation and maintaining immune homeostasis. Accordingly …

Genetically engineered T cells are powerful new medicines, offering hope for curative
responses in patients with cancer. Chimaeric antigen receptors (CARs) are a class of …

Regulatory T (Treg) cells suppress inflammation and regulate immune system activity. In
patients with systemic or organ-specific autoimmune diseases or those receiving …

One of the most exciting new therapies for cancer involves the use of autologous T cells that
are engineered to recognize and destroy cancerous cells. Patients with previously …

CD8+ T cells are involved in the pathogenesis of inflammatory bowel disease (IBD), a
complex multifactorial chronic disease. Here, we present an overview of the current research …

Adoptive immunotherapy with regulatory T cells (Tregs) is a promising treatment for allograft
rejection and graft-versus-host disease (GVHD). Emerging data indicate that, compared with …

Adoptive immunotherapy with Tregs is a promising approach for preventing or treating type
1 diabetes. Islet antigen–specific Tregs have more potent therapeutic effects than polyclonal …

Regulatory T cell (Treg) therapy using recipient-derived Tregs expanded ex vivo is currently
being investigated clinically by us and others as a means of reducing allograft rejection …