BACKGROUND Infertility is a major issue in human reproductive health, affecting an
estimated 15% of couples worldwide. Infertility can result from disorders of sex development …

BACKGROUND Primary ovarian insufficiency (POI) is characterized by marked
heterogeneity, but with a significant genetic contribution. Identifying exact causative genes …

Infertility affects~ 7% of couples of reproductive age with little change in incidence in the last
two decades. ART, as well as other interventions, have made major strides in correcting this …

Menopause is the final step in the process referred to as ovarian ageing. The age related
decrease in follicle numbers dictates the onset of cycle irregularity and the final cessation of …

BACKGROUND Initially identified for their capability to induce heterotopic bone formation,
bone morphogenetic proteins (BMPs) are multifunctional growth factors that belong to the …

Bone Morphogenetic Proteins (BMPs) are potent growth factors belonging to the
Transforming Growth Factor Beta superfamily. To date over 20 members have been …

Understanding the physiology underlying the complex dialog between the oocyte and its
surrounding somatic cells within the ovarian follicle has been crucial in defining optimal …

Primary ovarian insufficiency (POI) is determined by exhaustion of follicles in the ovaries,
which leads to infertility before the age of 40 years. It is characterized by a strong familial …

Transforming growth factor β (TGF-β) superfamily signaling pathways are ubiquitous and
essential regulators of cellular processes including proliferation, differentiation, migration …

Primary ovarian insufficiency (POI) is characterized by a loss of ovarian function before the
age of 40 and account for one major cause of female infertility. POI relevance is continuously …