Melatonin as modulator for sulfur and nitrogen mustard-induced inflammation, oxidative stress and DNA damage: Molecular therapeutics

E Ramos, E Gil-Martín, C De Los Ríos, J Egea… - Antioxidants, 2023 - mdpi.com
Sulfur and nitrogen mustards, bis (2-chloroethyl) sulfide and tertiary bis (2-chloroethyl)
amines, respectively, are vesicant warfare agents with alkylating activity. Moreover …

Toxic blister agents: Chemistry, mode of their action and effective treatment strategies

A Nair, P Yadav, A Behl, RK Sharma… - Chemico-biological …, 2021 - Elsevier
Since their use during the First World War, Blister agents have posed a major threat to the
individuals and have caused around two million casualties. Major incidents occurred not …

Flexible and MOF-808 uniformly assembled polyimide nanofiber membranes with excellent mechanical properties for rapid degradation of chemical warfare agents

Z Cheng, X Li, L Zhang, Z Yuan, H Zheng, H Guo… - Chemical Engineering …, 2023 - Elsevier
Breathable and soft protective clothing with self-disinfection function is crucial for the
practical application of protecting the human body from being killed by corrosive agents …

Role of hair follicles in the pathogenesis of arsenical‐induced cutaneous damage

RK Srivastava, Y Wang, J Khan… - Annals of the New …, 2022 - Wiley Online Library
Arsenical vesicants cause skin inflammation, blistering, and pain. The lack of appropriate
animal models causes difficulty in defining their molecular pathogenesis. Here, Ptch1+ …

The Multiple Functions of Melatonin: Applications in the Military Setting

G Gancitano, RJ Reiter - Biomedicines, 2022 - mdpi.com
The aim of this review is to provide the reader with a general overview on the rationale for
the use of melatonin by military personnel. This is a technique that is being increasingly …

[HTML][HTML] Alkylating agent-induced toxicity and melatonin-based therapies

J Egea, F López-Muñoz… - Frontiers in …, 2022 - frontiersin.org
Alkylating agents (AAs), are a group of chemo drugs generally divided into six classes;
triazenes, nitrogen mustards, nitrosoureas, ethylenimine and methylenamine derivatives …

[PDF][PDF] In vivo assessment of skin chemical burns in exposure to vesicants and the efficacy of an antidote formula in different pharmaceutical forms. an experimental …

CA Secară, A Catrina, OC Voinea, SS Dinu… - …, 2022 - farmaciajournal.com
The aim of this project was the histopathological and immunofluorescence evaluation of the
cutaneous toxicity of the vesicant chemical compound 2-chloroethyl-ethyl sulphide (CEES) …

Methimazole, an Effective Neutralizing Agent of the Sulfur Mustard Derivative 2-Chloroethyl Ethyl Sulfide

A Armoo, T Diemer, A Donkor, J Fedorchik… - ACS bio & med …, 2023 - ACS Publications
Sulfur mustard (SM), designated by the military as HD, is a highly toxic and dangerous
vesicant that has been utilized as a chemical warfare agent since World War I. Despite SM's …

In Vitro and In Vivo Characteristics of Olive Oil as Excipient for Topical Administration

M Rodríguez-Torrado, A Kara, S Torrado, A Romero… - Pharmaceutics, 2022 - mdpi.com
Oily excipients are vital components of dermatological products. In this study, the in vitro and
in vivo characteristics of Wild Olive Oil (WOO) were compared with two other types of olive …

Nitrogen Mustard Induced Protein Influx in Nucleus and Metabolism Change and p97 Mediated the Repair

J Cheng, W Yu, H Liu, X Dong, Y Sai, F Ye, G Dan… - 2023 - researchsquare.com
Nitrogen mustard (NM) can alkylate nucleophilic proteins and DNA, causing severe cell
damage. However, there are no reports on NM-induced proteomics dynamic changes. In this …