Cellular pathways that repair chromosomal double-strand breaks (DSBs) have pivotal roles
in cell growth, development and cancer. These DSB repair pathways have been the target of …

DNA double-strand breaks (DSBs) are the most dangerous type of DNA damage because
they can result in the loss of large chromosomal regions. In all mammalian cells, DSBs that …

Activation-Induced cytidine Deaminase (AID) initiates affinity maturation and isotype
switching by deaminating deoxycytidines within immunoglobulin genes, leading to somatic …

Immunoglobulin (Ig) class switch recombination (CSR) is the gene rearrangement process
by which B lymphocytes change the Ig heavy chain constant region to permit a switch of Ig …

Cellular DNA is constantly being damaged by numerous internal and external mutagenic
factors. Probably the most severe type of insults DNA could suffer are the double-strand …

Off-target or random integration of exogenous DNA hampers precise genomic engineering
and presents a safety risk in clinical gene therapy strategies. Genetic definition of random …

DNA double strand breaks (DSBs) are induced by external genotoxic agents (ionizing
radiation or genotoxins) or by internal processes (recombination intermediates in …

Immunoglobulin (Ig) class switch recombination (CSR) is the process occurring in mature B
cells that diversifies the effector component of antibody responses. CSR is initiated by the …

The integrity of the genome is under constant threat of environmental and endogenous
agents that cause DNA damage. Endogenous damage is particularly pervasive, occurring at …

The gene encoding DNA polymerase θ (Polθ) was discovered over ten years ago as having
a role in suppressing genome instability in mammalian cells. Studies have now clearly …