Systemic sclerosis
ER Volkmann, K Andréasson, V Smith - The Lancet, 2023 - thelancet.com
Systemic sclerosis, also known as scleroderma, is a rare and complex autoimmune
connective-tissue disease. Once considered an untreatable and unpredictable condition …
connective-tissue disease. Once considered an untreatable and unpredictable condition …
Inflammation and DNA damage: cause, effect or both
Inflammation is a biological response involving immune cells, blood vessels and mediators
induced by endogenous and exogenous stimuli, such as pathogens, damaged cells or …
induced by endogenous and exogenous stimuli, such as pathogens, damaged cells or …
[HTML][HTML] Current advances in the treatment of systemic sclerosis
H Bukiri, ER Volkmann - Current opinion in pharmacology, 2022 - Elsevier
Systemic sclerosis (SSc) is a rare, systemic autoimmune disease of unknown etiology.
Among the systemic rheumatic diseases, SSc carries the highest mortality, in part due to the …
Among the systemic rheumatic diseases, SSc carries the highest mortality, in part due to the …
[HTML][HTML] Endothelial dysfunction in systemic sclerosis
E Patnaik, M Lyons, K Tran, D Pattanaik - International Journal of …, 2023 - mdpi.com
Systemic sclerosis, commonly known as scleroderma, is an autoimmune disorder
characterized by vascular abnormalities, autoimmunity, and multiorgan fibrosis. The exact …
characterized by vascular abnormalities, autoimmunity, and multiorgan fibrosis. The exact …
[HTML][HTML] When natural antibodies become pathogenic: autoantibodies targeted against G protein-coupled receptors in the pathogenesis of systemic sclerosis
R Akbarzadeh, A Müller, JY Humrich… - Frontiers in …, 2023 - frontiersin.org
Systemic sclerosis (SSc) is a chronic, multisystem connective tissue, and autoimmune
disease with the highest case-specific mortality and complications among rheumatic …
disease with the highest case-specific mortality and complications among rheumatic …
[HTML][HTML] Genomic instability in early systemic sclerosis
Abstract Objectives Systemic sclerosis (SSc) is associated with secondary malignancies.
Previous studies have suggested that mutated cancer proteins, such as RNA polymerase III …
Previous studies have suggested that mutated cancer proteins, such as RNA polymerase III …
[HTML][HTML] Decreased serum levels of SIRT1 and SIRT3 correlate with severity of skin and lung fibrosis and peripheral microvasculopathy in systemic sclerosis
Systemic sclerosis (SSc, scleroderma) is a severe autoimmune connective tissue disease
characterized by widespread peripheral microvasculopathy, and progressive cutaneous and …
characterized by widespread peripheral microvasculopathy, and progressive cutaneous and …
[HTML][HTML] Protein profiling in systemic sclerosis patients with different pulmonary complications using proteomic antibody microarray
J Huang, H Zhu, S Liu, M Li, Y Li, H Luo… - Arthritis Research & …, 2024 - Springer
Background Pulmonary arterial hypertension (PAH) and interstitial lung disease (ILD) are
leading causes of systemic sclerosis (SSc)-related death. In this study, we aimed to identify …
leading causes of systemic sclerosis (SSc)-related death. In this study, we aimed to identify …
[HTML][HTML] The involvement of smooth muscle, striated muscle, and the myocardium in Scleroderma: a review
Systemic sclerosis (SSc) is a complex autoimmune disease characterized by heterogeneous
changes involving numerous organs and systems. The currently available data indicate that …
changes involving numerous organs and systems. The currently available data indicate that …
[HTML][HTML] Complement component C4 structural variation and quantitative traits contribute to sex-biased vulnerability in systemic sclerosis
M Kerick, M Acosta-Herrera, CP Simeón-Aznar… - NPJ genomic …, 2022 - nature.com
Copy number (CN) polymorphisms of complement C4 play distinct roles in many conditions,
including immune-mediated diseases. We investigated the association of C4 CN with …
including immune-mediated diseases. We investigated the association of C4 CN with …