[HTML][HTML] Genetics factors in major depression disease
M Shadrina, EA Bondarenko, PA Slominsky - Frontiers in psychiatry, 2018 - frontiersin.org
Depressive disorders (DDs) are one of the most widespread forms of psychiatric pathology.
According to the World Health Organization, about 350 million people in the world are …
According to the World Health Organization, about 350 million people in the world are …
[HTML][HTML] Mitoferrin, cellular and mitochondrial iron homeostasis
Iron is essential for many cellular processes, but cellular iron homeostasis must be
maintained to ensure the balance of cellular signaling processes and prevent disease. Iron …
maintained to ensure the balance of cellular signaling processes and prevent disease. Iron …
[HTML][HTML] Transcriptome-wide association study identifies new susceptibility genes and pathways for depression
X Li, X Su, J Liu, H Li, M Li… - Translational …, 2021 - nature.com
Depression is the most prevalent mental disorder with substantial morbidity and mortality.
Although genome-wide association studies (GWASs) have identified multiple risk variants …
Although genome-wide association studies (GWASs) have identified multiple risk variants …
Genetic variants in major depressive disorder: from pathophysiology to therapy
In spite of promising preclinical results there is a decreasing number of new registered
medications in major depression. The main reason behind this fact is the lack of confirmation …
medications in major depression. The main reason behind this fact is the lack of confirmation …
[HTML][HTML] Membrane transporters involved in iron trafficking: physiological and pathological aspects
A Pasquadibisceglie, MC Bonaccorsi di Patti, G Musci… - Biomolecules, 2023 - mdpi.com
Iron is an essential transition metal for its involvement in several crucial biological functions,
the most notable being oxygen storage and transport. Due to its high reactivity and potential …
the most notable being oxygen storage and transport. Due to its high reactivity and potential …
[HTML][HTML] Whole-genome sequencing analysis of suicide deaths integrating brain-regulatory eQTLs data to identify risk loci and genes
Recent large-scale genome-wide association studies (GWAS) have started to identify
potential genetic risk loci associated with risk of suicide; however, a large portion of suicide …
potential genetic risk loci associated with risk of suicide; however, a large portion of suicide …
[HTML][HTML] Antidepressant drug-specific prediction of depression treatment outcomes from genetic and clinical variables
Individuals with depression differ substantially in their response to treatment with
antidepressants. Specific predictors explain only a small proportion of these differences. To …
antidepressants. Specific predictors explain only a small proportion of these differences. To …
[HTML][HTML] C/EBPβ Regulates TFAM Expression, Mitochondrial Function and Autophagy in Cellular Models of Parkinson's Disease
A Sierra-Magro, F Bartolome, D Lozano-Muñoz… - International Journal of …, 2023 - mdpi.com
Parkinson's disease (PD) is a neurodegenerative disorder that results from the degeneration
of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Since there are only …
of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Since there are only …
Therapy response prediction in major depressive disorder: current and novel genomic markers influencing pharmacokinetics and pharmacodynamics
A Shalimova, V Babasieva, VN Chubarev… - …, 2021 - Taylor & Francis
Major depressive disorder is connected with high rates of functional disability and mortality.
About a third of the patients are at risk of therapy failure. Several pharmacogenetic markers …
About a third of the patients are at risk of therapy failure. Several pharmacogenetic markers …
[HTML][HTML] Integrative genomics analysis of various omics data and networks identify risk genes and variants vulnerable to childhood-onset asthma
X Ma, P Wang, G Xu, F Yu, Y Ma - BMC Medical Genomics, 2020 - Springer
Background Childhood-onset asthma is highly affected by genetic components. In recent
years, many genome-wide association studies (GWAS) have reported a large group of …
years, many genome-wide association studies (GWAS) have reported a large group of …