[HTML][HTML] Genetics factors in major depression disease

M Shadrina, EA Bondarenko, PA Slominsky - Frontiers in psychiatry, 2018 - frontiersin.org
Depressive disorders (DDs) are one of the most widespread forms of psychiatric pathology.
According to the World Health Organization, about 350 million people in the world are …

[HTML][HTML] Mitoferrin, cellular and mitochondrial iron homeostasis

MY Ali, CR Oliva, S Flor, CE Griguer - Cells, 2022 - mdpi.com
Iron is essential for many cellular processes, but cellular iron homeostasis must be
maintained to ensure the balance of cellular signaling processes and prevent disease. Iron …

[HTML][HTML] Transcriptome-wide association study identifies new susceptibility genes and pathways for depression

X Li, X Su, J Liu, H Li, M Li… - Translational …, 2021 - nature.com
Depression is the most prevalent mental disorder with substantial morbidity and mortality.
Although genome-wide association studies (GWASs) have identified multiple risk variants …

Genetic variants in major depressive disorder: from pathophysiology to therapy

X Gonda, P Petschner, N Eszlari, D Baksa… - Pharmacology & …, 2019 - Elsevier
In spite of promising preclinical results there is a decreasing number of new registered
medications in major depression. The main reason behind this fact is the lack of confirmation …

[HTML][HTML] Membrane transporters involved in iron trafficking: physiological and pathological aspects

A Pasquadibisceglie, MC Bonaccorsi di Patti, G Musci… - Biomolecules, 2023 - mdpi.com
Iron is an essential transition metal for its involvement in several crucial biological functions,
the most notable being oxygen storage and transport. Due to its high reactivity and potential …

[HTML][HTML] Whole-genome sequencing analysis of suicide deaths integrating brain-regulatory eQTLs data to identify risk loci and genes

S Han, E DiBlasi, ET Monson, A Shabalin, E Ferris… - Molecular …, 2023 - nature.com
Recent large-scale genome-wide association studies (GWAS) have started to identify
potential genetic risk loci associated with risk of suicide; however, a large portion of suicide …

[HTML][HTML] Antidepressant drug-specific prediction of depression treatment outcomes from genetic and clinical variables

R Iniesta, K Hodgson, D Stahl, K Malki, W Maier… - Scientific reports, 2018 - nature.com
Individuals with depression differ substantially in their response to treatment with
antidepressants. Specific predictors explain only a small proportion of these differences. To …

[HTML][HTML] C/EBPβ Regulates TFAM Expression, Mitochondrial Function and Autophagy in Cellular Models of Parkinson's Disease

A Sierra-Magro, F Bartolome, D Lozano-Muñoz… - International Journal of …, 2023 - mdpi.com
Parkinson's disease (PD) is a neurodegenerative disorder that results from the degeneration
of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Since there are only …

Therapy response prediction in major depressive disorder: current and novel genomic markers influencing pharmacokinetics and pharmacodynamics

A Shalimova, V Babasieva, VN Chubarev… - …, 2021 - Taylor & Francis
Major depressive disorder is connected with high rates of functional disability and mortality.
About a third of the patients are at risk of therapy failure. Several pharmacogenetic markers …

[HTML][HTML] Integrative genomics analysis of various omics data and networks identify risk genes and variants vulnerable to childhood-onset asthma

X Ma, P Wang, G Xu, F Yu, Y Ma - BMC Medical Genomics, 2020 - Springer
Background Childhood-onset asthma is highly affected by genetic components. In recent
years, many genome-wide association studies (GWAS) have reported a large group of …