Plant specialized metabolites (PSMs) play essential roles in the adaptation to harsh
environments and function in plant defense responses. PSMs act as key components of …

Plants are a rich source of bioactive compounds, many of which have been exploited for
cosmetic, nutritional, and medicinal purposes. Through the characterization of metabolic …

Plant genomes remain highly fragmented and are often characterized by hundreds to
thousands of assembly gaps. Here, we report chromosome-level reference and phased …

Camptothecin is a chemotherapeutic drug widely used to treat various cancers. Ophiorrhiza
pumila is an ideal plant model for the study of camptothecin production, with various …

SUMMARY Neolamarckia cadamba (Roxb.), a close relative of Coffea canephora and
Ophiorrhiza pumila, is an important traditional medicine in Southeast Asia. Three major …

The limited bioavailability of plant-derived natural products with anticancer activity poses
major challenges to the pharmaceutical industry. An example of this is camptothecin, a …

Plants produce a large variety of low-molecular-weight and specialized secondary
compounds. Among them, nitrogen-containing alkaloids are the most biologically active and …

Abstract Camptothecin (CPT), a well-known natural anti-cancer drug, is produced from
woody plant Camptotheca acuminata. Up to now, two CPT-derivatives, irinotecan and …

Abstract Camptothecin (CPT), a well-known monoterpenoid indole alkaloid with broad-
spectrum anti-cancer activity, is produced from plants and endophytes. In view of the …

The plant kingdom abounds in countless species with potential medical uses. Many of them
contain valuable secondary metabolites belonging to different classes and demonstrating …