Liver cancer is the third most common cause of cancer-related deaths in the world and has
become an urgent problem for global public health. Bioactive substances are widely used …

The Programmed death-1 (PD-1) and its programmed death-ligand 1 (PD-L1) comprise the
PD-1/PD-L1 axis and maintain tumor immune evasion. Cancer immunotherapy based on …

A biological process called epithelial-mesenchymal transition (EMT) allows epithelial cells to
change into mesenchymal cells and acquire some cancer stem cell properties. EMT …

Natural products and medicinal herbs have been used to treat various human diseases by
regulating cellular functions and metabolic pathways. Angelica gigas NAKAI (AG) helps …

The identification of anticancer active ingredients and their molecular targets in traditional
Chinese medicine is a great challenge in modern pharmacology research. Evodiamine is …

Abstract Ethnopharmacological relevance Wuji Wan (WJW) is a traditional Chinese
medicine formula that can be found in the" Prescriptions of Taiping Benevolent Dispensary" …

Natural product evodiamine is a multitargeting antitumor lead compound. However, clinical
development of evodiamine derivatives was hampered by poor water solubility and limited …

Purpose Liver cancer is considered as the third leading cause of cancer-related deaths, with
hepatocellular carcinoma (HCC) accounting for approximately 90% of liver cancers …

Background Evodiamine (EVO) is one of the primary components of Evodia rutaecarpa and
has been found to have a positive therapeutic effect on various digestive system diseases …

Mitochondria are the membrane-bound organelles producing energy for cellular metabolic
processes. They orchestrate diverse cell signaling cascades regulating cellular …