The immune system plays a critical role in shaping all facets of cancer, from the early
initiation stage through to metastatic disease and resistance to therapy. Our understanding …

Like most solid tumours, the microenvironment of epithelial-derived gastric adenocarcinoma
(GAC) consists of a variety of stromal cell types, including fibroblasts, and neuronal …

The gastric microbiome has been proposed as an etiological factor in gastric
carcinogenesis. We compared the gastric microbiota in subjects presenting with gastric …

While Helicobacter pylori is a fundamental risk factor, gastric cancer (GC) aetiology involves
combined effects of microbial (both H. pylori and non-H. pylori), host and environmental …

The nucleotide-binding oligomerization domain (NOD) protein, NOD2, belonging to the
intracellular NOD-like receptor family, detects conserved motifs in bacterial peptidoglycan …

Toll-like receptors (TLRs) are a family of transmembrane receptors that recognize various
pathogen-and damage-associated molecular pattern molecules playing an important role in …

Gastric cancer is the end result of a complex interplay between host genetics, environmental
factors, and microbial factors. The link between gut microbiome and gastric cancer has been …

Chronic inflammation is the primary cause of gastric cancer (GC). NLRP3, as an important
inflammasome component, has crucial roles in initiating inflammation. However, the …

Chronic mucosal pathogens have evolved multiple strategies to manipulate the host
immune response; consequently, microbes contribute to the development of> 2 million …

Helicobacter pylori is a late-in-life human pathogen with potential early-life benefits.
Although H. pylori is disappearing from the human population, little is known about the …