Mass spectrometry is unmatched in its versatility for studying practically any aspect of the
proteome. Because the foundations of mass spectrometry-based proteomics are complex …

The E4 allele of Apolipoprotein E (APOE) is associated with both metabolic dysfunction and
a heightened pro-inflammatory response: two findings that may be intrinsically linked …

BACKGROUND: The adult mammalian heart is incapable of regeneration, whereas a
transient regenerative capacity is maintained in the neonatal heart, primarily through the …

Research into how the young and old differ, and which biomarkers reflect the diverse
biological processes underlying ageing, is a current and fast-growing field. Biological clocks …

The multiple hypothesis testing problem is inherent in large-scale quantitative “omic”
experiments such as mass spectrometry-based proteomics. Yet, tools for comparing the …

Tissue damage elicits a wound healing response of inflammation and remodeling aimed at
restoring homeostasis. Dysregulation of wound healing leads to accumulation of effector …

Aging is associated with progressive phenotypic changes. Virtually all cellular phenotypes
are produced by proteins, and their structural alterations can lead to age-related diseases …

The brain's neuroreparative capacity after injuries such as ischemic stroke is contained in
the brain's neurogenic niches, primarily the subventricular zone (SVZ), which lies in close …

Tissue aging can be viewed as a loss of normal maintenance; in advanced age, the
mechanisms which keep the tissue healthy on daily bases fail to manage the accumulating …

Here, we provide a step-by-step protocol for the collection and intracerebroventricular
infusion of cerebrospinal fluid (CSF) in mice. We describe steps to withdraw CSF quickly and …