Background: The connection between uric acid (UA) and renal impairment is well known
due to the urate capacity to precipitate within the tubules or extra-renal system. Emerging …

Cardiovascular disease (CVD) is a major cause of mortality worldwide. A better
understanding of the mechanisms underlying CVD is key for better management or …

Background Higher serum urate levels are associated with an increased risk of diabetic
kidney disease. Lowering of the serum urate level with allopurinol may slow the decrease in …

A continuous supply of oxygen is essential for the survival of multicellular organisms. The
understanding of how this supply is regulated in the microvasculature has evolved from …

This review aims to critically present the available clinical evidence supporting the treatment
of chronic hyperuricemia with xanthine oxidase inhibitors. For this reason, the studies …

Uric acid is the final product of purine metabolism. Hyperuricemia is defined as a condition
where the level of uric acid exceeds the normal range. The most well-known disease …

Regular physical activity is a cornerstone in the prevention and treatment of atherosclerotic
cardiovascular disease (CVD) due to its positive effects in reducing several cardiovascular …

Renal proximal tubular cells (PTECs) participate in several mechanisms of innate immunity,
express toll‐like receptors (TLRs), and proinflammatory cytokines. Hyperuricemia may be a …

This is an overview of the metabolic reactions of drugs, natural products, physiological
compounds, and other (general) chemicals catalyzed by flavin monooxygenase (FMO) …

Introduction: The significant proportion of gout patients not reaching serum urate levels
below 6.0 mg/dL and the debated pathogenicity of hyperuricemia (HU) itself motivate …