Sensory neurons with cell bodies situated in dorsal root ganglia convey information from
external or internal sites of the body such as actual or potential harm, temperature or muscle …

Chronic pain is a highly prevalent debilitating condition for which treatment options remain
limited for many patients. Ionotropic ATP signalling through excitatory and calcium …

Abstract ATP-dependent P2X3 receptors play a crucial role in the sensitization of nerve
fibers and pathological pain pathways. They are also involved in pathways triggering cough …

Chronic pain is a debilitating condition that often occurs following peripheral tissue
inflammation and nerve injury. This pain, especially neuropathic pain, is a significant clinical …

Biological differences in sensory processing between human and model organisms may
present significant obstacles to translational approaches in treating chronic pain. To better …

Brain inflammation is a common occurrence following responses to varied insults such as
bacterial infections, stroke, traumatic brain injury and neurodegenerative disorders. A …

Although species-specific differences in ion channel properties are well-documented, little
has been known about the properties of the human Nav1. 8 channel, an important …

Current therapies for the treatment of chronic pain provide inadequate relief for millions of
suffering patients, demonstrating the need for better therapies that will treat pain effectively …

Transcripts and/or proteins of P2X receptor (P2XR) subunits have been found in virtually all
mammalian tissues. Generally more than one of the seven known P2X subunits have been …

A sensory role for ATP was proposed long before general acceptance of its extracellular
role. ATP activates and sensitizes signal transmission at multiple sites along the sensory …