The controlled cortical impact model: applications, considerations for researchers, and future directions
ND Osier, CE Dixon - Frontiers in neurology, 2016 - frontiersin.org
Controlled cortical impact (CCI) is a mechanical model of traumatic brain injury (TBI) that
was developed nearly 30 years ago with the goal of creating a testing platform to determine …
was developed nearly 30 years ago with the goal of creating a testing platform to determine …
Applications of the Morris water maze in translational traumatic brain injury research
Acquired traumatic brain injury (TBI) is frequently accompanied by persistent cognitive
symptoms, including executive function disruptions and memory deficits. The Morris Water …
symptoms, including executive function disruptions and memory deficits. The Morris Water …
Microglial depletion with CSF1R inhibitor during chronic phase of experimental traumatic brain injury reduces neurodegeneration and neurological deficits
Chronic neuroinflammation with sustained microglial activation occurs following severe
traumatic brain injury (TBI) and is believed to contribute to subsequent neurodegeneration …
traumatic brain injury (TBI) and is believed to contribute to subsequent neurodegeneration …
Inhibition of autophagy in microglia and macrophages exacerbates innate immune responses and worsens brain injury outcomes
N Hegdekar, C Sarkar, S Bustos, RM Ritzel… - Autophagy, 2023 - Taylor & Francis
Excessive and prolonged neuroinflammation following traumatic brain injury (TBI)
contributes to long-term tissue damage and poor functional outcomes. However, the …
contributes to long-term tissue damage and poor functional outcomes. However, the …
Impaired autophagy flux is associated with neuronal cell death after traumatic brain injury
C Sarkar, Z Zhao, S Aungst, B Sabirzhanov, AI Faden… - Autophagy, 2014 - Taylor & Francis
Dysregulation of autophagy contributes to neuronal cell death in several neurodegenerative
and lysosomal storage diseases. Markers of autophagy are also increased after traumatic …
and lysosomal storage diseases. Markers of autophagy are also increased after traumatic …
Repeated mild traumatic brain injury causes chronic neuroinflammation, changes in hippocampal synaptic plasticity, and associated cognitive deficits
SL Aungst, SV Kabadi, SM Thompson… - Journal of Cerebral …, 2014 - journals.sagepub.com
Repeated mild traumatic brain injury (mTBI) can cause sustained cognitive and psychiatric
changes, as well as neurodegeneration, but the underlying mechanisms remain unclear. We …
changes, as well as neurodegeneration, but the underlying mechanisms remain unclear. We …
Spinal cord injury causes brain inflammation associated with cognitive and affective changes: role of cell cycle pathways
Experimental spinal cord injury (SCI) causes chronic neuropathic pain associated with
inflammatory changes in thalamic pain regulatory sites. Our recent studies examining …
inflammatory changes in thalamic pain regulatory sites. Our recent studies examining …
Old age increases microglial senescence, exacerbates secondary neuroinflammation, and worsens neurological outcomes after acute traumatic brain injury in mice
After traumatic brain injury (TBI), individuals aged over 65 years show increased mortality
and worse functional outcomes compared with younger persons. As neuroinflammation is a …
and worse functional outcomes compared with younger persons. As neuroinflammation is a …
PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma
Lysosomal membrane permeabilization (LMP) is observed under many pathological
conditions, leading to cellular dysfunction and death. However, the mechanisms by which …
conditions, leading to cellular dysfunction and death. However, the mechanisms by which …
Traumatic brain injury induces cGAS activation and type I interferon signaling in aged mice
JP Barrett, SM Knoblach, S Bhattacharya… - Frontiers in …, 2021 - frontiersin.org
Aging adversely affects inflammatory processes in the brain, which has important
implications in the progression of neurodegenerative disease. Following traumatic brain …
implications in the progression of neurodegenerative disease. Following traumatic brain …