Apoptosis and its therapeutic implications in neurodegenerative diseases

NS Erekat - Clinical Anatomy, 2022 - Wiley Online Library
Neurodegenerative disorders are characterized by progressive loss of particular populations
of neurons. Apoptosis has been implicated in the pathogenesis of neurodegenerative …

Relationships between stress granules, oxidative stress, and neurodegenerative diseases

L Chen, B Liu - Oxidative medicine and cellular longevity, 2017 - Wiley Online Library
Cytoplasmic stress granules (SGs) are critical for facilitating stress responses and for
preventing the accumulation of misfolded proteins. SGs, however, have been linked to the …

AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of …

B Szczesny, K Módis, K Yanagi, C Coletta… - Nitric oxide, 2014 - Elsevier
The purpose of the current study was to investigate the effect of the recently synthesized
mitochondrially-targeted H 2 S donor, AP39 [(10-oxo-10-(4-(3-thioxo-3H-1, 2-dithiol-5yl) …

H2S‐Releasing Versatile Montmorillonite Nanoformulation Trilogically Renovates the Gut Microenvironment for Inflammatory Bowel Disease Modulation

T Jin, H Lu, Q Zhou, D Chen, Y Zeng, J Shi… - Advanced …, 2024 - Wiley Online Library
Abnormal activation of the intestinal mucosal immune system, resulting from damage to the
intestinal mucosal barrier and extensive invasion by pathogens, contributes to the …

The signaling mechanisms of hippocampal endoplasmic reticulum stress affecting neuronal plasticity-related protein levels in high fat diet-induced obese rats and the …

M Cai, H Wang, J Li, YL Zhang, L Xin, F Li… - Brain, behavior, and …, 2016 - Elsevier
High fat diet (HFD)-induced obesity has been shown to reduce the levels of neuronal
plasticity-related proteins, specifically brain-derived neurotrophic factor (BDNF) and …

Stress granule: a promising target for cancer treatment

X Gao, L Jiang, Y Gong, X Chen, M Ying… - British journal of …, 2019 - Wiley Online Library
Stress granules (SGs) are primarily composed of mRNAs that stall at translation initiation
and usually appear in the cytoplasm under unusual physiological or pathological conditions …

[HTML][HTML] Effect of alcohol on the central nervous system to develop neurological disorder: pathophysiological and lifestyle modulation can be potential therapeutic …

Z Pervin, JM Stephen - AIMS neuroscience, 2021 - ncbi.nlm.nih.gov
The central nervous system (CNS) is the major target for adverse effects of alcohol and
extensively promotes the development of a significant number of neurological diseases such …

PGC-1α sparks the fire of neuroprotection against neurodegenerative disorders

J Lv, S Jiang, Z Yang, W Hu, Z Wang, T Li… - Ageing research reviews, 2018 - Elsevier
Recently, growing evidence has demonstrated that peroxisome proliferator activated
receptor γ (PPARγ) coactivator-1α (PGC-1α) is a superior transcriptional regulator that acts …

Oxidative stress as a therapeutic target in amyotrophic lateral sclerosis: Opportunities and limitations

HR Park, EJ Yang - Diagnostics, 2021 - mdpi.com
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND) and Lou
Gehrig's disease, is characterized by a loss of the lower motor neurons in the spinal cord …

Protective roles of Amanita caesarea polysaccharides against Alzheimer's disease via Nrf2 pathway

Z Li, X Chen, Y Zhang, X Liu, C Wang, L Teng… - International journal of …, 2019 - Elsevier
This study explores the neuro-protective effects of Amanita caesarea polysaccharides
(ACPS), obtained by 80% alcohol precipitation of water extract and purified using a DEAE …