Recent identification of oncogenic cells within healthy tissues and the prevalence of indolent
cancers found incidentally at autopsies reveal a greater complexity in tumor initiation than …

Epithelial stem cells accumulate mutations throughout life. Some of these mutants increase
competitive fitness and may form clones that colonize the stem cell niche and persist to …

Cancer is among the most common causes of death for dogs (and cats) and humans in the
developed world, even though it is uncommon in wildlife and other domestic animals. We …

Aging represents the major risk factor for the development of cancer and many other
diseases. Recent findings show that normal tissues become riddled with expanded clones …

Oxidative stress–induced DNA damage and its repair systems are related to cancer etiology;
however, the molecular basis triggering tumorigenesis is not well understood. Here, we …

The relationship between intestinal stem cells (ISCs) and colorectal cancer (CRC) has been
a topic of intense study. Uncovering stem cell dynamics in homeostasis and following …

Pathogenic or likely pathogenic (P/LP) germline TP53 variants are the primary cause of Li-
Fraumeni syndrome (LFS), a hereditary cancer predisposition disorder characterized by …

Aging modifies risk in all cancers, but age is used as a clinical staging criterion uniquely in
thyroid cancer (TC). The molecular drivers of age-dependent TC onset and aggressiveness …

Introduction Local and regional recurrence after surgical intervention is a significant problem
in cancer management. The multistage theory of carcinogenesis precisely places the …

The accumulation of somatic mutations is a driver of cancer and has long been associated
with ageing. Due to limitations in quantifying mutation burden with age in non-cancerous …