Disorders of sex development

SF Witchel - Best Practice & Research Clinical Obstetrics & …, 2018 - Elsevier
Highlights•Sex development depends on spatio-temporal sequence & coordination of
mutually antagonistic activating & repressing factors.•Disorders of sex development can be …

Genetic regulation of mammalian gonad development

S Eggers, T Ohnesorg, A Sinclair - Nature Reviews Endocrinology, 2014 - nature.com
Sex-specific gonadal development starts with formation of the bipotential gonad, which then
differentiates into either a mature testis or an ovary. This process is dependent on activation …

Society for Endocrinology UK guidance on the initial evaluation of an infant or an adolescent with a suspected disorder of sex development (Revised 2015)

SF Ahmed, JC Achermann, W Arlt, A Balen… - Clinical …, 2016 - Wiley Online Library
It is paramount that any child or adolescent with a suspected disorder of sex development
(DSD) is assessed by an experienced clinician with adequate knowledge about the range of …

Disorders of sex development: new genes, new concepts

M Ono, VR Harley - Nature Reviews Endocrinology, 2013 - nature.com
Formerly known as' intersex'conditions, disorders of sex development (DSDs) are congenital
conditions in which chromosomal, gonadal or anatomical sex is atypical. A complete …

Normal male sexual differentiation and aetiology of disorders of sex development

RA Rey, RP Grinspon - Best Practice & Research Clinical Endocrinology & …, 2011 - Elsevier
Fetal sex development consists of three sequential stages: a) the undifferentiated stage,
when identical primitive structures develop in the XY and XX embryos, b) gonadal …

Disorders of sexual development: current status and progress in the diagnostic approach

M García-Acero, O Moreno, F Suárez, A Rojas - Current urology, 2020 - karger.com
Disorders of sexual development (DSD) are conditions with an atypical chromosomal,
gonadal or phenotypic sex, which leads to differences in the development of the urogenital …

Satisfaction with genital surgery and sexual life of adults with XY disorders of sex development: results from the German clinical evaluation study

B Köhler, E Kleinemeier, A Lux, O Hiort… - The Journal of …, 2012 - academic.oup.com
Background: Prenatal deficit of androgens or androgen action results in atypical genitalia in
individuals with XY disorders of sex development (XY, DSD). XY, DSD include mainly …

Sex change in clownfish: molecular insights from transcriptome analysis

L Casas, F Saborido-Rey, T Ryu, C Michell, T Ravasi… - Scientific reports, 2016 - nature.com
Sequential hermaphroditism is a unique reproductive strategy among teleosts that is
displayed mainly in fish species living in the coral reef environment. The reproductive …

UK guidance on the initial evaluation of an infant or an adolescent with a suspected disorder of sex development

SF Ahmed, JC Achermann, W Arlt… - Clinical …, 2011 - Wiley Online Library
It is paramount that any child or adolescent with a suspected disorder of sex development
(DSD) is assessed by an experienced clinician with adequate knowledge about the range of …

Next generation sequencing (NGS) to improve the diagnosis and management of patients with disorders of sex development (DSD)

LA Hughes, K McKay-Bounford, EA Webb… - Endocrine …, 2019 - ec.bioscientifica.com
Disorders of sex development (DSDs) are a diverse group of conditions where the
chromosomal, gonadal or anatomical sex can be atypical. The highly heterogeneous nature …